Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2590-y
Abstract: Bile acid prodrugs have served as a viable strategy for refining the pharmaceutical profile of parent drugs through utilizing bile acid transporters. A series of three ester prodrugs of the antiherpetic drug acyclovir (ACV) with… read more here.
Keywords: acv; hsv; plasma stability; antiviral activity ... See more keywords
AB0809 A STUDY TO COMPARE ARTICULAR CARTILAGE VOLUME IN HEALTHY AND OSTEOARTHRITIC KNEE AND ITS CORRELATION WITH CLINICO – RADIOLOGICAL SEVERITY
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.6708
Abstract: Background Knee Osteoarthritis (KOA) is a persistent debilitating disease characterized by loss of articular cartilage. Known to be a disease of elderly, it may not be necessarily so, as the loss in articular cartilage volume… read more here.
Keywords: acv; articular cartilage; correlation; severity ... See more keywords
Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Neurology"
DOI: 10.1155/2017/5238402
Abstract: Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous… read more here.
Keywords: acv; acyclovir ivig; effects acyclovir; treated mice ... See more keywords