BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202306499
Abstract: EZH2 is the catalytic subunit of the histone methyltransferase Polycomb Repressive Complex 2 (PRC2), and its somatic activating mutations drive lymphoma, particularly the germinal center B‐cell type. Although PRC2 inhibitors, such as tazemetostat, have demonstrated… read more here.
Keywords: prc2 inhibitors; efficacy prc2; acvr1; efficacy ... See more keywords
Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis
Sign Up to like & getrecommendations! Published in 2025 at "Gut Microbes"
DOI: 10.1080/19490976.2025.2463581
Abstract: ABSTRACT Helicobacter pylori (H. pylori) infection plays a pivotal role in gastric carcinogenesis through inflammation-related mechanisms. Activin A receptor type I (ACVR1), known for encoding the type I receptor for bone morphogenetic proteins (BMPs), has… read more here.
Keywords: acvr1; pold1; infection; gastric tumorigenesis ... See more keywords
OR23-06 Sensory neuronal ACVR1-mediated neuroimmune contribution to neuropathic pain and heterotopic ossification in fibrodysplasia ossificans progressiva
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.565
Abstract: Abstract Disclosure: X. Yu: None. J. Braz: None. L. Lam: None. K. Bhardwaji: None. K. Jin: None. H. Yuan: None. D. Mohsenin: None. E. Yu: None. J. Weinrich: None. B. Ahanonu: None. A. Basbaum: None.… read more here.
Keywords: none; contribution; pain; sensory neuronal ... See more keywords