Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102
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DOI: 10.1158/1078-0432.ccr-22-0470
Abstract: Abstract Purpose: To investigate the metabolism of synovial sarcoma (SS) and elucidate the effect of malic enzyme 1 absence on SS redox homeostasis. Experimental Design: ME1 expression was measured in SS clinical samples, SS cell… read more here.
Keywords: ferroptosis induction; me1 null; me1 absence; absence ... See more keywords
Abstract 3322: Sigma-2-Erastin inhibits PC tumor growth through lipid ROS-DUSP6-MAPK signaling
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DOI: 10.1158/1538-7445.am2024-3322
Abstract: Introduction: Pancreatic cancer (PC) is a malignancy with poor prognosis and high mortality with a very low 5-year survival rate. Currently, apoptosis and autophagy are the central mechanisms of programmed cell death (PCD) that maintain… read more here.
Keywords: acxt 3102; lipid ros; dusp6 mapk; tumor ... See more keywords