Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine and a Five‐Membered Heterocycle as Selective Inhibitors of Plasmodial 6‐Oxopurine Phosphoribosyltransferases
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700293
Abstract: Acyclic nucleoside phosphonates (ANPs) are an important class of therapeutic drugs that act as antiviral agents by inhibiting viral DNA polymerases and reverse transcriptases. ANPs containing a 6‐oxopurine unit instead of a 6‐aminopurine or pyrimidine… read more here.
Keywords: nucleoside phosphonates; membered heterocycle; five membered; deazahypoxanthine five ... See more keywords
N2' -Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300211
Abstract: Twelve N2'-branched acyclic nucleoside phosphonates and bisphosphonates were synthesized as potential inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT), the key enzyme in the purine salvage pathway for production of purine nucleotides. The chemical structures were… read more here.
Keywords: plasmodium falciparum; nucleoside phosphonates; branched acyclic; acyclic nucleoside ... See more keywords
Evaluation of ODE‐Bn‐PMEG, an acyclic nucleoside phosphonate prodrug, as an antiviral against productive HPV infection in 3D organotypic epithelial cultures
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.12.013
Abstract: HighlightsODE‐Bn‐PMEG abolishes human papillomavirus productive infection in 3D cultures of primary human keratinocytes (PHKs).Incorporation of activated ODE‐Bn‐PMEG into replicating DNA causes DNA breaks and abolishes viral activities.ODE‐Bn‐PMEG induces apoptosis selectively in HPV‐infected, differentiated keratinocytes while… read more here.
Keywords: acyclic nucleoside; ode pmeg; nucleoside phosphonate; infection ... See more keywords
C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113798
Abstract: Some pathogens, including parasites of the genus Trypanosoma causing Human and Animal African Trypanosomiases, cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Thus, their… read more here.
Keywords: nucleoside phosphonates; brucei adenine; trypanosoma brucei; adenosine monophosphate ... See more keywords
Coordination Chemistry of Nucleotides and Antivirally Active Acyclic Nucleoside Phosphonates, including Mechanistic Considerations
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092625
Abstract: Considering that practically all reactions that involve nucleotides also involve metal ions, it is evident that the coordination chemistry of nucleotides and their derivatives is an essential corner stone of biological inorganic chemistry. Nucleotides are… read more here.
Keywords: chemistry nucleotides; coordination chemistry; coordination; chemistry ... See more keywords
Preparation of New Oxadiazole Acyclic Nucleoside and Thioglycoside Analogs Containing Chromene Moiety with Antimicrobial Evaluation
Sign Up to like & getrecommendations! Published in 2017 at "Revista De Chimie"
DOI: 10.37358/rc.17.10.5861
Abstract: New sugar hydrazones linked to chroman ring system and their derived oxadiazole acyclic nucleoside analogs were synthesized from the substituted ethyl ester oxime derivative. The 2-sustituted 1,3,4-oxadiazole5-thione prepared from acid hydrazide was glycosylated to afford… read more here.
Keywords: new oxadiazole; thioglycoside analogs; preparation new; oxadiazole acyclic ... See more keywords