Acyclovir for Mechanically Ventilated Patients With Herpes Simplex Virus Oropharyngeal Reactivation: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2019.5713
Abstract: Importance The role of herpes simplex virus (HSV) reactivation on morbidity and mortality in patients in the intensive care unit requiring mechanical ventilation remains unknown. Objective To determine whether preemptive treatment with intravenous acyclovir reduces… read more here.
Keywords: trial; reactivation; acyclovir; mechanical ventilation ... See more keywords
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.11.002
Abstract: ABSTRACT Pritelivir, a helicase‐primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir‐resistant strains, were treated 72 h… read more here.
Keywords: pritelivir; hsv; treatment; simplex encephalitis ... See more keywords
Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00668
Abstract: When the nucleoside analogue acyclovir was introduced in the early 1980s, it presented a game-changing treatment modality for herpes simplex virus infections. Since then, work has been ongoing to improve the weaknesses that have now… read more here.
Keywords: virus infections; chemistry; simplex virus; acyclovir ... See more keywords
Feasibility of Enhancing Skin Permeability of Acyclovir through Sterile Topical Lyophilized Wafer on Self-Dissolving Microneedle-Treated Skin
Sign Up to like & getrecommendations! Published in 2022 at "Dose-Response"
DOI: 10.1177/15593258221097594
Abstract: Acyclovir is an antiviral drug that is frequently prescribed for the herpes virus. However, the drug requires frequent dosing due to limited bioavailability (10–26.7%). The rationale of the present study was to develop a self-dissolving… read more here.
Keywords: dissolving microneedle; self dissolving; acyclovir; wafer ... See more keywords
Effect of acyclovir solid lipid nanoparticles for treatment of Herpes Simplex Virus (HSV) infection in an animal model of HSV-1 infection.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738507666190829161737
Abstract: BACKGROUND Acyclovir use is limited by a high frequency of administration of five times a day and low bioavailability. This leads to poor patient compliance. OBJECTIVES To overcome the problem of frequent dosing, we used… read more here.
Keywords: hsv infection; acyclovir; model; nanotechnology ... See more keywords
Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112311
Abstract: Background: Acyclovir and valacyclovir are used for the treatment and prophylaxis of infections with herpes simplex virus (HSV) and varicella zoster virus (VZV). The aim of this study is to provide insight into the pharmacodynamics… read more here.
Keywords: acyclovir; immunocompromised patients; model; varicella zoster ... See more keywords
[Comparison of Antiviral Effect of Olive Leaf Extract and Propolis with Acyclovir on Herpes Simplex Virus Type 1].
Sign Up to like & getrecommendations! Published in 2020 at "Mikrobiyoloji bulteni"
DOI: 10.5578/mb.69019
Abstract: While acyclovir, a nucleoside analogue, is widely used for herpes simplex virus type 1 (HSV-1), emergence of drug-resistant viruses due to frequent usage of this class of medicines, and their toxic side effects require exploring… read more here.
Keywords: hsv; propolis; hour; acyclovir ... See more keywords