Human Fatty Acid Synthase: A Computational Study of the Transfer of the Acyl Moieties from MAT to the ACP Domain
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900548
Abstract: Human Fatty Acid Synthase (hFAS) is a multidomain enzyme responsible for the biosynthesis of saturated fatty acids, which are crucial for numerous biological processes. During the biosynthetic reaction, hFAS incorporates acetyl and malonyl moieties through… read more here.
Keywords: human fatty; fatty acid; acyl; acp domain ... See more keywords
Quantification of Acyl-Acyl Carrier Proteins for Fatty Acid Synthesis Using LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1362-7_13
Abstract: The fatty acid biosynthetic cycle is predicated on an acyl carrier protein (ACP) scaffold where two carbon acetyl groups are added in a chain elongation process through a series of repeated enzymatic steps. The chain… read more here.
Keywords: protein; chain; fatty acid; acyl carrier ... See more keywords
The R117A variant of the Escherichia coli transacylase FabD synthesizes novel acyl-(acyl carrier proteins)
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8586-9
Abstract: The commercial impact of fermentation systems producing novel and biorenewable chemicals will flourish with the expansion of enzymes engineered to synthesize new molecules. Though a small degree of natural variability exists in fatty acid biosynthesis,… read more here.
Keywords: fabd; acp; acyl; r117a variant ... See more keywords
Patterns of inheritance of acylsugar acyl groups in selected interspecific hybrids of genus Nicotiana
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Plant Research"
DOI: 10.1007/s10265-020-01188-x
Abstract: Glandular trichomes on the surface of Solanaceae species produce acyl sugars that are species-, and cultivar-specific. Acyl sugars are known to possess insecticidal, antibiotic, and hormone-like properties, and as such have great potential as a… read more here.
Keywords: acyl sugars; acyl; acylsugar acyl; patterns inheritance ... See more keywords
Atomistic Insight on Structure and Dynamics of Spinach Acyl Carrier Protein with Substrate Length.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.12.036
Abstract: The plant acyl-acyl carrier protein (ACP) desaturases are a family of soluble enzymes that convert saturated fatty-acyl ACPs into their cis-monounsaturated equivalents in an oxygen-dependent reaction. These enzymes play a key role in biosynthesis of… read more here.
Keywords: structure dynamics; carrier protein; acyl carrier; acyl ... See more keywords
Cobalt and nickel affect the fluidity of negatively-charged biomimetic membranes.
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2017.11.016
Abstract: Elevated levels of the essential trace metals cobalt and nickel are associated with a variety of toxic effects, which are not well-understood, and may involve interactions with the lipid membrane. Fluidity changes of biomimetic lipid… read more here.
Keywords: nickel affect; negatively charged; acyl; affect fluidity ... See more keywords
Photoresponsive N,N′-disubstituted indigo derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108197
Abstract: Abstract The synthesis and a comprehensive characterization of the excited state properties of five N,N′-substituted indigo (Ind) derivatives (acetyl-, benzoyl-, methoxybenzoyl-, nitrobenzoyl- and chlorobenzoyl-) was undertaken in various solvents and temperatures. In the excited state,… read more here.
Keywords: excited state; acyl derivatives; acyl; photoresponsive disubstituted ... See more keywords
Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.02.008
Abstract: Peroxisomal acyl-CoA oxidase 1a (ACOX1a) catalyzes the first and rate-limiting step of fatty acid oxidation, the conversion of acyl-CoAs to 2-trans-enoyl-CoAs. The dysfunction of human ACOX1a (hACOX1a) leads to deterioration of the nervous system manifesting… read more here.
Keywords: peroxisomal acyl; crystal structures; coa oxidase; acyl ... See more keywords
Novel acyl carbamates and acyl / diacyl ureas show in vitro efficacy against Toxoplasma gondii and Cryptosporidium parvum
Sign Up to like & getrecommendations! Published in 2020 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2020.08.006
Abstract: Toxoplasma gondii and Cryptosporidium parvum are protozoan parasites that are highly prevalent and opportunistically infect humans worldwide, but for which completely effective and safe medications are lacking. Herein, we synthesized a series of novel small… read more here.
Keywords: toxoplasma gondii; parvum; acyl; gondii cryptosporidium ... See more keywords
Structure-guided reshaping of the acyl binding pocket of 'TesA thioesterase enhances octanoic acid production in E. coli.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2020.04.010
Abstract: Medium-chain fatty acids (C6-C10) have attracted much attention recently for their unique properties compared to their long-chain counterparts, including low melting points and relatively higher carbon conversion yield. Thioesterase enzymes, which can catalyze the hydrolysis… read more here.
Keywords: chain; production; binding pocket; acyl ... See more keywords
Multicomponent Reaction of Isocyanide, Ditelluride, and Mn(III) Carboxylate: Synthesis of N-Acyl Tellurocarbamate.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00824
Abstract: A multicomponent reaction of isocyanides, ditellurides and manganese(III) carboxylates under mild reaction conditions leads to the synthesis of various N-acyl tellurocarbamates. This method demonstrates good functional tolerance and broad substrate scope and, as a result,… read more here.
Keywords: iii; synthesis; acyl; reaction ... See more keywords