Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.
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DOI: 10.1021/acsmedchemlett.1c00285
Abstract: Ligand-directed bioconjugation strategies have been used for selective protein labeling in live cells or tissue samples in applications such as live-cell imaging. Here we hypothesized that a similar strategy could be used for targeted protein… read more here.
Keywords: degradation; acyl alkylsulfonamide; chemistry; acylation ... See more keywords