Potassium-Base-Mediated Autoxidative Diastereoselective Homocoupling of N-Acyl-2-aminoacetophenones.
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DOI: 10.1021/acs.orglett.2c00618
Abstract: We herein report a general and highly efficient method for the synthesis of dl-2,3-diamide-1,4-diones via autoxidative dehydrogenative homocoupling of N-acyl-2-aminoacetophenones mediated by t-BuOK. The transformation is mild, operationally simple, and environmentally friendly. Control experiments and… read more here.
Keywords: potassium base; base mediated; acyl aminoacetophenones; homocoupling acyl ... See more keywords