REGIO- AND DIASTEREOSELECTIVE SYNTHESIS OF N -SUBSTITUTED 2-ACYL-3-ARYL-3,5-DIHYDROFURO[3,2- c ]PYRIDIN-4(2 H )-ONES
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DOI: 10.1007/5898
Abstract: Трехкомпонентной конденсацией генерируемых in situ ацилметилидов пиридиния с ароматическими альдегидами и 4-гидрокси-6-метилпиридонами получена серия 3-арил-2-ацил-3,5-дигидрофуро[3,2- c ]пиридин-4(2 H )-онов. Реакция протекает диастереоселективно с образованием транс -изомеров и представляет собой каскадный процесс, включающий конденсацию Кнёвенагеля, карбо-реакцию… read more here.
Keywords: diastereoselective synthesis; synthesis substituted; regio diastereoselective; acyl aryl ... See more keywords
Regio- and diastereoselective synthesis of N-substituted 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones
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DOI: 10.1007/s10593-020-02832-z
Abstract: The three-component condensation of pyridinium acylmethylides generated in situ with aromatic aldehydes and 4-hydroxy-6-methylpyridones gave a series of 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones. The reaction proceeds diastereoselectively with the formation of trans-isomers and represents a cascade process involving the… read more here.
Keywords: dihydrofuro pyridin; regio diastereoselective; pyridin ones; acyl aryl ... See more keywords