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   Articles with "acyl chain" as a keyword



The many faces (and phases) of ceramide and sphingomyelin II – binary mixtures

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recommendations! Published in 2017 at "Biophysical Reviews"

DOI: 10.1007/s12551-017-0298-y

Abstract: A rather widespread idea on the functional importance of sphingolipids in cell membranes refers to the occurrence of ordered domains enriched in sphingomyelin and ceramide that are largely assumed to exist irrespective of the type… read more here.

Keywords: chain length; ceramide sphingomyelin; ceramides sphingomyelins; miscibility ... See more keywords

The substrate selectivity of the two homologous SGNH hydrolases from Streptomyces bacteria: Molecular dynamics and experimental study.

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recommendations! Published in 2020 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2020.04.198

Abstract: Two extracellular enzymes of the SGNH hydrolase superfamily reveal highly homologous 3D structures, but act on different substrates; one is a true phospholipase A1 from Streptomyces albidoflavus (SaPLA1, EC: 3.1.1.32, PDB code: 4HYQ), whereas the… read more here.

Keywords: chain; attached position; molecular dynamics; chain attached ... See more keywords
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Resolving Modifications on Sphingoid Base and N-Acyl Chain of Sphingomyelin Lipids in Complex Lipid Extracts.

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recommendations! Published in 2020 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.0c03502

Abstract: Sphingomyelins (SMs) are an essential class of lipids widely existing in different organisms. The sphingoid base and N-acyl chain are two building blocks which can undergo different types of modifications during lipogenesis, including desaturation, hydroxylation,… read more here.

Keywords: base acyl; base; sphingoid base; acyl chain ... See more keywords
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Ceramide structure dictates glycosphingolipid nanodomain assembly and function

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-23961-9

Abstract: Gangliosides in the outer leaflet of the plasma membrane of eukaryotic cells are essential for many cellular functions and pathogenic interactions. How gangliosides are dynamically organized and how they respond to ligand binding is poorly… read more here.

Keywords: function; ceramide; acyl chain; structure ... See more keywords

ETMR-20. CARDIOLIPIN ACYL CHAIN MODULATION AS A NOVEL MITOCHONDRIAL-FOCUSED THERAPEUTIC TARGET IN ETMR

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.190

Abstract: Abstract Embryonal tumor with multilayered rosettes (ETMR) is a highly aggressive CNS neoplasm that occurs almost exclusively in infants and is associated with an extremely poor prognosis. Dysregulated mitochondrial bioenergetics and dynamics have been associated… read more here.

Keywords: acyl chain; cardiolipin acyl; embryonal tumor; cardiolipin ... See more keywords

Natural Variation Meets Synthetic Biology: Promiscuous Trichome-Expressed Acyltransferases from Nicotiana.

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recommendations! Published in 2022 at "Plant physiology"

DOI: 10.1093/plphys/kiac192

Abstract: Acylsugars are defensive, trichome-synthesized sugar esters produced in plants across the Solanaceae (nightshade) family. Although assembled from simple metabolites and synthesized by a relatively short core biosynthetic pathway, tremendous within- and across-species acylsugar structural variation… read more here.

Keywords: synthetic biology; variation; trichome; biology ... See more keywords

Fatty acyl recognition and transfer by an integral membrane S-acyltransferase

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recommendations! Published in 2018 at "Science"

DOI: 10.1126/science.aao6326

Abstract: Fattening up proteins Many eukaryotic proteins are modified by the attachment of lipids, and these modifications can alter how proteins interact with cellular membranes. Rana et al. present x-ray crystal structures of an integral membrane… read more here.

Keywords: chain; fatty acyl; dhhc; membrane ... See more keywords

Enhancement of Sphingolipid Synthesis Improves Osmotic Tolerance of Saccharomyces cerevisiae

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recommendations! Published in 2020 at "Applied and Environmental Microbiology"

DOI: 10.1128/aem.02911-19

Abstract: This study demonstrated a novel strategy for the manipulation of membrane complex sphingolipids to enhance S. cerevisiae tolerance to osmotic stress. Elo2, a sphingolipid acyl chain elongase, was related to osmotic tolerance through transcriptome analysis… read more here.

Keywords: tolerance; acyl chain; type strain; osmotic tolerance ... See more keywords

PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids

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recommendations! Published in 2020 at "Journal of Lipid Research"

DOI: 10.1194/jlr.ra120001087

Abstract: The plasma membrane of neurons consists of distinct domains, each of which carries specialized functions and a characteristic set of membrane proteins. While this compartmentalized membrane organization is essential for neuronal functions, it remains controversial… read more here.

Keywords: membrane proteins; acyl chain; membrane; chain remodeling ... See more keywords
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The effect of cardiolipin side chain composition on cytochrome c protein conformation and peroxidase activity

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recommendations! Published in 2021 at "Physiological Reports"

DOI: 10.14814/phy2.14772

Abstract: Skeletal muscle, a highly active tissue, makes up 40% of the total body weight. This tissue relies on mitochondria for ATP production, calcium homeostasis, and programed cell death. Mitochondrial phospholipid composition, namely, cardiolipin (CL), influences… read more here.

Keywords: chain; peroxidase; chain composition; composition ... See more keywords

Reducing the endotoxic activity or enhancing the vaccine immunogenicity by altering the length of lipid A acyl chain in Salmonella.

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recommendations! Published in 2023 at "International immunopharmacology"

DOI: 10.2139/ssrn.4217349

Abstract: The balance of the attenuation and reactogenicity is an issue in the development of recombinant attenuated Salmonella vaccines (RASV). Some reactogenic strains produced side effects are partially induced by lipid A. As reported, the number… read more here.

Keywords: lipid acyl; salmonella; acyl; length ... See more keywords