Crystal structure of the rice acyl‐CoA‐binding protein OsACBP2 in complex with C18:3‐CoA reveals a novel pattern of binding to acyl‐CoA esters
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13923
Abstract: Acyl‐CoA‐binding proteins (ACBPs) are a family of proteins that bind acyl‐CoA esters at a conserved acyl‐CoA‐binding domain. ACBPs maintain intracellular acyl‐CoA pools to regulate lipid metabolism. Here, we report on the structure of rice OsACBP2… read more here.
Keywords: osacbp2; c18 coa; acyl coa; coa ... See more keywords
The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14415
Abstract: Mitochondria are involved in many cellular activities, including energy metabolism and biosynthesis of nucleotides, fatty acids and amino acids. Mitochondrial morphology is a key factor in dictating mitochondrial functions. Here, we report that the acyl‐CoA‐binding… read more here.
Keywords: binding protein; coa binding; lipid droplets; acb1 regulates ... See more keywords
Acyl‐CoA synthetase short‐chain family member 2 (ACSS2) is regulated by SREBP‐1 and plays a role in fatty acid synthesis in caprine mammary epithelial cells
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DOI: 10.1002/jcp.25954
Abstract: Sterol regulatory element binding protein 1 (SREBP‐1) is well‐known as the master regulator of lipogenesis in rodents. Acyl‐CoA synthetase short‐chain family member 2 (ACSS2) plays a key role in lipogenesis by synthesizing acetyl‐CoA from acetate… read more here.
Keywords: fatty acid; lipogenesis; acyl coa; acss2 ... See more keywords
Prediction of disease severity in multiple acyl‐CoA dehydrogenase deficiency: A retrospective and laboratory cohort study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12147
Abstract: Multiple acyl‐CoA dehydrogenase deficiency (MADD) is an ultra‐rare inborn error of mitochondrial fatty acid oxidation (FAO) and amino acid metabolism. Individual phenotypes and treatment response can vary markedly. We aimed to identify markers that predict… read more here.
Keywords: madd ds3; disease severity; multiple acyl; acyl coa ... See more keywords
Enantiomer‐specific pharmacokinetics of D,L‐3‐hydroxybutyrate: Implications for the treatment of multiple acyl‐CoA dehydrogenase deficiency
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12365
Abstract: D,L‐3‐hydroxybutyrate (D,L‐3‐HB, a ketone body) treatment has been described in several inborn errors of metabolism, including multiple acyl‐CoA dehydrogenase deficiency (MADD; glutaric aciduria type II). We aimed to improve the understanding of enantiomer‐specific pharmacokinetics of… read more here.
Keywords: coa dehydrogenase; specific pharmacokinetics; acyl coa; enantiomer specific ... See more keywords
Growing evidence for a role for acyl‐CoA synthetase 1 in immunometabolism
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DOI: 10.1002/jlb.3ce0519-154r
Abstract: Discussion on the role of acyl-CoA synthetase 1 in immunometabolism. read more here.
Keywords: synthetase immunometabolism; acyl coa; coa synthetase; role acyl ... See more keywords
Comment on: “Multiple acyl‑CoA dehydrogenase deficiency in elderly carriers”
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09752-0
Abstract: We read the paper “Multiple acyl‐CoA dehydrogenase defi‐ ciency [MADD] in elderly carriers” by Macchione et al. with great interest, where they describe two elderly individuals, each with only one heterozygous variant in ETFDH gene… read more here.
Keywords: coa dehydrogenase; variant; elderly carriers; acyl coa ... See more keywords
Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-018-1460-3
Abstract: Benzoate (found in milk and widely used as preservative), salicylate (present in fruits and the active component of aspirin), dietary polyphenols produced by gut microbiota, metabolites from organic acidemias, and medium-chain fatty acids (MCFAs) are… read more here.
Keywords: protein expression; medium chain; acsm2a acsm2b; acyl coa ... See more keywords
A liquid chromatography tandem mass spectrometry method for semiquantitative screening of cellular acyl-CoA.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114430
Abstract: This study describes LC-ESI-MS/MS method that covers the analysis of various cellular acyl-CoA in a single injection. The method is based on a quick extraction step eliminating LLE/SPE clean up. Method performance characteristics were determined… read more here.
Keywords: method; acyl coa; cellular acyl; coa ... See more keywords
Mouse long-chain Acyl-CoA synthetase 1 is active as a monomer.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108773
Abstract: Fatty acids are essential cellular building blocks and a major energy source. Regardless of their metabolic fate, fatty acids first need to be activated by forming a thioester with a coenzyme A group. This reaction… read more here.
Keywords: active monomer; acyl coa; long chain; coa ... See more keywords
Novel ACOX1 mutations in two siblings with peroxisomal acyl-CoA oxidase deficiency
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DOI: 10.1016/j.braindev.2020.10.011
Abstract: Peroxisomal acyl-CoA oxidase (ACOX1) deficiency is a rare autosomal recessive single enzyme deficiency characterized by hypotonia, seizures, failure to thrive, developmental delay, and neurological regression starting from approximately 3 years of age. Here, we report two… read more here.
Keywords: peroxisomal acyl; acyl coa; acox1 deficiency; two siblings ... See more keywords