The role of OleA His285 in orchestration of long‐chain acyl‐coenzyme A substrates
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13004
Abstract: Renewable production of hydrocarbons is being pursued as a petroleum‐independent source of commodity chemicals and replacement for biofuels. The bacterial biosynthesis of long‐chain olefins represents one such platform. The process is initiated by OleA catalyzing… read more here.
Keywords: olea; acyl coenzyme; long chain; role ... See more keywords
Epilepsy and inborn errors of metabolism in adults: The diagnostic odyssey of a young woman with medium‐chain acyl‐coenzyme A dehydrogenase deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12630
Abstract: We describe a case of epileptic encephalopathy in a young woman with undiagnosed medium‐chain acyl‐coenzyme A dehydrogenase deficiency (MCADD), who presented with an early‐onset focal motor status epilepticus (SE) then followed by permanent left hemiplegia… read more here.
Keywords: young woman; etiology; acyl coenzyme; chain acyl ... See more keywords
Acyl Coenzyme A Thioesterase 9: A Novel Target for Nonalcoholic Fatty Liver Disease by Shuttling Mitochondrial Short‐Chain Fatty Acids?
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31450
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease globally. It can progress to the more severe nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). The liver is a major site for lipid… read more here.
Keywords: fatty liver; acyl coenzyme; disease; nonalcoholic fatty ... See more keywords
Identification of adaptive inhibitors of Cryptosporidium parvum fatty acyl-coenzyme A synthetase isoforms by virtual screening
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06445-0
Abstract: Cryptosporidiosis is a significant cause of gastroenteritis in both humans and livestock in developing countries. The only FDA-approved drug available against the same is nitazoxanide, with questionable efficacy in malnourished children and immunocompromised patients. Recent… read more here.
Keywords: virtual screening; cryptosporidium parvum; acyl coenzyme; coenzyme synthetase ... See more keywords
IpdE1-IpdE2 Is a Heterotetrameric Acyl Coenzyme A Dehydrogenase That Is Widely Distributed in Steroid-Degrading Bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00005
Abstract: Steroid-degrading bacteria, including Mycobacterium tuberculosis (Mtb), utilize an architecturally distinct subfamily of acyl coenzyme A dehydrogenases (ACADs) for steroid catabolism. These ACADs are α2β2 heterotetramers that are usually encoded by adjacent fadE-like genes. In mycobacteria,… read more here.
Keywords: acyl coenzyme; ipde1 ipde2; degrading bacteria; steroid degrading ... See more keywords
Engineered Production of Short-Chain Acyl-Coenzyme A Esters in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.7b00466
Abstract: Short-chain acyl-coenzyme A esters serve as intermediate compounds in fatty acid biosynthesis, and the production of polyketides, biopolymers and other value-added chemicals. S. cerevisiae is a model organism that has been utilized for the biosynthesis of… read more here.
Keywords: production; acyl coenzyme; short chain; coa ... See more keywords
Identification by High-Throughput Screening of Pseudomonas Acyl–Coenzyme A Synthetase Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "SLAS Discovery"
DOI: 10.1177/2472555216689283
Abstract: Pseudomonas infections are common among hospitalized, immunocompromised, and chronic lung disease patients. These infections are recalcitrant to common antibacterial therapies due to inherent antibiotic resistance. To meet the need of new anti-Pseudomonas drugs, a sensitive,… read more here.
Keywords: screening pseudomonas; pseudomonas acyl; acyl coenzyme; identification high ... See more keywords
A novel mutation in ACADVL causing very long-chain acyl-coenzyme-A dehydrogenase deficiency in a South Asian pediatric patient: a case report and review of the literature
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Case Reports"
DOI: 10.1186/s13256-021-03013-y
Abstract: Background Very long-chain acyl-coenzyme-A dehydrogenase deficiency is a rare, severe life-threatening metabolic disorder of mitochondrial fatty acid oxidation, caused by mutations in ACADVL gene. Here we present a genetically confirmed case of a South Asian… read more here.
Keywords: acyl coenzyme; dehydrogenase deficiency; case; long chain ... See more keywords
Glycogen storage disease type Ia misdiagnosed as multiple acyl-coenzyme A dehydrogenase deficiency by mass spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.999596
Abstract: Objective To report a case of glycogen storage disease (GSD) type Ia misdiagnosed as multiple acyl-coenzyme a dehydrogenase deficiency (MADD) by mass spectrometry. Methods A 7 months old boy was admitted to our hospital for… read more here.
Keywords: multiple acyl; dehydrogenase; dehydrogenase deficiency; mass spectrometry ... See more keywords
Expression Plasticity of Peroxisomal Acyl-Coenzyme A Oxidase Genes Implies Their Involvement in Redox Regulation in Scallops Exposed to PST-Producing Alexandrium
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20080472
Abstract: Filter-feeding bivalves can accumulate paralytic shellfish toxins (PST) produced by toxic microalgae, which may induce oxidative stress and lipid peroxidation. Peroxisomal acyl-coenzyme A oxidases (ACOXs) are key enzymes functioning in maintaining redox and lipid homeostasis,… read more here.
Keywords: pst; pst producing; expression; acyl coenzyme ... See more keywords