Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00366
Abstract: Acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs and products of their transformations have long been implicated in drug-induced liver injury (DILI). To inform on the DILI risk arising from AG reactive intermediates, a comprehensive… read more here.
Keywords: better understanding; acyl glucuronide; understanding acyl; driving better ... See more keywords
Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.078329
Abstract: Clopidogrel acyl glucuronide (CLP-G) is a major phase II metabolite of clopidogrel generated in the liver for further excretion into urine; however, it is unclear whether CLP-G transports from hepatocytes into blood. Because multidrug resistance-associated… read more here.
Keywords: clp; acyl glucuronide; mrp3 transports; mrp3 ... See more keywords
In Vitro Evidence of Potential Interactions between CYP2C8 and Candesartan Acyl-β-D-glucuronide in the Liver
Sign Up to like & getrecommendations! Published in 2021 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000126
Abstract: Growing evidence suggests that certain glucuronides function as potent inhibitors of CYP2C8. We previously reported the possibility of drug-drug interactions between candesartan cilexetil and paclitaxel. In this study, we evaluated the effects of candesartan N2-glucuronide… read more here.
Keywords: candesartan acyl; candesartan; acyl glucuronide; drug ... See more keywords