Combinatorial Optimization of Activity-Based Probes for Acyl Protein Thioesterases 1 and 2.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00174
Abstract: Acyl protein thioesterases hydrolyze fatty acid thioesters on cysteine residues of proteins. The two protein depalmitoylases APT1 and APT2 have a very high degree of similarity and show substantial overlap in substrate utility. Potent, selective,… read more here.
Keywords: based probes; activity based; acyl protein; protein thioesterases ... See more keywords
Protein depalmitoylases
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DOI: 10.1080/10409238.2017.1409191
Abstract: Abstract Protein depalmitoylation describes the removal of thioester-linked long chain fatty acids from cysteine residues in proteins. For many S-palmitoylated proteins, this process is promoted by acyl protein thioesterase enzymes, which catalyze thioester hydrolysis to… read more here.
Keywords: protein; protein depalmitoylases; protein thioesterase; depalmitoylation ... See more keywords
Development of an activity-based probe for acyl-protein thioesterases
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DOI: 10.1371/journal.pone.0190255
Abstract: Protein palmitoylation is a dynamic post-translational modification (PTM) important for cellular functions such as protein stability, trafficking, localization, and protein-protein interactions. S-palmitoylation occurs via the addition of palmitate to cysteine residues via a thioester linkage,… read more here.
Keywords: protein; probe; activity based; protein thioesterases ... See more keywords
Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.956231
Abstract: Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic and… read more here.
Keywords: protein acylation; acylation; acyl protein; protein thioesterases ... See more keywords