Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.
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DOI: 10.1021/acsmedchemlett.7b00363
Abstract: Farnesoid X receptor (FXR) plays a major role in the control of cholesterol metabolism. Antagonizing transcriptional activity of FXR is an effective means to treat the relevant metabolic syndrome. Some of antagonists so far have… read more here.
Keywords: fxr; receptor fxr; acylated piperidine; nonacidic chemotype ... See more keywords