N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance
Sign Up to like & getrecommendations! Published in 2021 at "Neurotherapeutics"
DOI: 10.1007/s13311-021-01116-4
Abstract: Opioids are essential drugs for pain management, although long-term use is accompanied by tolerance, necessitating dose escalation, and dependence. Pharmacological treatments that enhance opioid analgesic effects and/or attenuate the development of tolerance (with a desirable… read more here.
Keywords: development; morphine; tolerance; inhibition ... See more keywords
Secretion, isotopic labeling and deglycosylation of N-acylethanolamine acid amidase for biophysical studies.
Sign Up to like & getrecommendations! Published in 2018 at "Protein expression and purification"
DOI: 10.1016/j.pep.2017.12.005
Abstract: N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) enzyme with a catalytic cysteine residue that has highest activity at acidic pH. The most prominent substrate hydrolyzed is palmitoylethanolamine (PEA), which regulates inflammation. Inhibitors of… read more here.
Keywords: acid amidase; acylethanolamine acid; isotopic labeling;