Antiparasitic activities of novel pyrimidine N‐acylhydrazone hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21745
Abstract: In this article, a series of 29 new pyrimidine N‐acylhydrazone hybrids were synthesized and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi protozoa that cause the neglected diseases cutaneous leishmaniasis and Chagas disease, respectively.… read more here.
Keywords: antiparasitic activities; activities novel; novel pyrimidine; acylhydrazone hybrids ... See more keywords
Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.003
Abstract: Twenty-four novel β-carboline/acylhydrazone hybrids were synthesized and evaluated for their in vitro antiproliferative activity. Among them, 12r exhibited the most potent activity, with IC50 values of 1-2 μM against panel of cancer cell lines and retained significant… read more here.
Keywords: novel carboline; acylhydrazone hybrids; discovery novel; carboline acylhydrazone ... See more keywords