Articles with "acylhydrazone hydrazine" as a keyword



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Atom-based 3D-QSAR, molecular docking, DFT, and simulation studies of acylhydrazone, hydrazine, and diazene derivatives as IN-LEDGF/p75 inhibitors

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Published in 2020 at "Structural Chemistry"

DOI: 10.1007/s11224-020-01628-3

Abstract: Since HIV-1 integrase makes use of host genome machinery to accomplish the replication process, where LEDGF/p75 (a cellular cofactor) executes in the lentiviral integration process by interacting with integrase. Thus, the integrase-LEDGF/p75 interaction has become… read more here.

Keywords: hydrazine diazene; atom based; diazene derivatives; ledgf p75 ... See more keywords