Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.
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DOI: 10.2139/ssrn.4202449
Abstract: Direct oral anticoagulants (DOACs), which includes thrombin and factor Xa inhibitors, have emerged as the preferred therapeutics for thrombotic disorders, penetrating a market previously dominated by warfarin and heparin. This article describes the discovery and… read more here.
Keywords: novel acylpyrazoles; discovery novel; thrombin inhibitors; acylpyrazoles potent ... See more keywords