Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.
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DOI: 10.1021/acs.jmedchem.1c00888
Abstract: This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas aeruginosa LpxA with no… read more here.
Keywords: acetylglucosamine acyltransferase; chemistry; acyltransferase lpxa; udp acetylglucosamine ... See more keywords