Citrullination of adenosine deaminase impairs its binding to dipeptidyl peptidase IV.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2022.106820
Abstract: The presence of citrullinated adenosine deaminase (ADA) was reported in the synovial fluids of rheumatoid arthritis individuals. This work reports the effects of ADA citrullination on the formation/stabilization of ADA complex with dipeptidyl peptidase IV… read more here.
Keywords: dipeptidyl peptidase; ada; citrullination; adenosine deaminase ... See more keywords
Diagnostic accuracy of ADA 2020 criteria for undiagnosed diabetes in a Peruvian population.
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2020.108475
Abstract: AIMS To assess the prevalence of undiagnosed diabetes (UDD) and the diagnostic accuracy of the American Diabetes Association (ADA) criteria to detect UDD cases in a Peruvian population. METHODS Population-based cross-sectional study. UDD was defined… read more here.
Keywords: ada; accuracy; diagnostic accuracy; undiagnosed diabetes ... See more keywords
Scaffold for liver tissue engineering: Exploring the potential of fibrin incorporated alginate dialdehyde-gelatin hydrogel.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.10.256
Abstract: INTRODUCTION Development of a tissue-engineered construct for hepatic regeneration remains a challenging task due to the lack of an optimum environment that support the growth of hepatocytes. Hydrogel systems possess many similarities with tissues and… read more here.
Keywords: liver tissue; hydrogel; ada; tissue ... See more keywords
Aflatoxins produced by Aspergillus parasiticus present in the diet of quails increase the activities of cholinesterase and adenosine deaminase.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.03.041
Abstract: The aim of this study was to evaluate the effects of aflatoxins on cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and adenosine deaminase (ADA) activities in quails. For this, twenty male quails were randomly distributed into… read more here.
Keywords: ache; ada; group; adenosine deaminase ... See more keywords
Targeting adenosine in SSc
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-0435-z
Abstract: Aberrant activation of adenosinedependent signalling has been implicated in a number of fibrotic diseases, including systemic sclerosis (SSc). The results of a new study indicate that adenosine depletion with recombinant pegylated adenosine deaminase (PEG-ADA) improves… read more here.
Keywords: ssc; ada; treatment; fra2 transgenic ... See more keywords
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40136
Abstract: Adenosine Deaminase (ADA) deficiency is an autosomal recessive variant of severe combined immunodeficiency (SCID) caused by systemic accumulation of ADA substrates. Neurological and behavioral abnormalities observed in ADA-SCID patients surviving after stem cell transplantation or… read more here.
Keywords: alterations brain; ada; brain adenosine; deficient mice ... See more keywords
Random acceleration and steered molecular dynamics simulations reveal the (un)binding tunnels in adenosine deaminase and critical residues in tunnels
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra07796h
Abstract: Adenosine deaminase (ADA) is an important enzyme related to purine nucleoside metabolism in human serum and various tissues. Abnormal ADA levels are related to a wide variety of diseases such as rheumatoid arthritis, AIDS, anemia,… read more here.
Keywords: molecular dynamics; ada; steered molecular; adenosine deaminase ... See more keywords
Age : pleural fluid ADA ratio and other indicators for differentiating between tubercular and malignant pleural effusions
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029788
Abstract: Most of pleural effusions are caused by tuberculosis and malignant tumor. Difficult sampling and bacterial sparing nature of these diseases challenge doctors’ diagnosis in China. This study aimed to develop a new convenient and effective… read more here.
Keywords: ada; age ada; fluid ada; age ... See more keywords
Evaluation of atezolizumab immunogenicity: Clinical pharmacology (part 1).
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and translational science"
DOI: 10.1111/cts.13127
Abstract: Baseline patient characteristics and prognostic factors are important considerations in oncology when evaluating the impact of immunogenicity on pharmacokinetics (PK) and efficacy. Here, we assessed the impact of anti-drug antibodies (ADA) on the PK of… read more here.
Keywords: immunogenicity; ada; exposure; pharmacology ... See more keywords
Diagnostic Value Of Adenosine Deaminase In Bronchoalveolar Lavage Fluid For Patients With Lung Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of clinical practice"
DOI: 10.1111/ijcp.14918
Abstract: BACKGROUND Lung cancer is both the most common seen malignity and cause of cancer-related deaths in worldwide. Adenosine deaminase (ADA) is a hydrolytic enzyme that catalyzes the conversion of adenosine to inosine in purine metabolism… read more here.
Keywords: patients lung; ada; ada levels; bronchoalveolar lavage ... See more keywords
OP0204 Impact of anti-drug antibody and injection site reaction on efficacy: 24-week results from a phase iii study comparing SB4 (etanercept biosimilar) with reference etanercept in patients with rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.3043
Abstract: Background SB4 is approved by the European Commission as a biosimilar of the reference etanercept (ETN). The phase III clinical study results have been reported previously.1,2 Data to date shows no correlation between the development… read more here.
Keywords: week; ada; group; efficacy ... See more keywords