Heterogeneous and evolving epitope landscape of clinical anti-drug antibodies against multidomain biotherapeutic: a case study of TAK-186
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DOI: 10.1080/19420862.2025.2587584
Abstract: ABSTRACT The emergence of anti-drug antibodies (ADAs) poses a major obstacle in the clinical development of therapeutic proteins (TPs) such as monoclonal antibodies and their derivatives. While standard multitiered ADA assays and neutralizing antibody assays… read more here.
Keywords: drug antibodies; anti drug; case study; ada epitope ... See more keywords