E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding.
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DOI: 10.1126/scisignal.adr7926
Abstract: The behavior of cells is governed by signals originating from their local environment, including mechanical forces exerted on the cells. Forces are transduced by mechanosensitive proteins, which can impinge on signaling cascades that are also… read more here.
Keywords: erk signaling; epithelial monolayers; adam mediated; egfr erk ... See more keywords