ADAM10 controls the differentiation of the coronary arterial endothelium
Sign Up to like & getrecommendations! Published in 2018 at "Angiogenesis"
DOI: 10.1007/s10456-018-9653-2
Abstract: The coronary vasculature is crucial for normal heart function, yet much remains to be learned about its development, especially the maturation of coronary arterial endothelium. Here, we show that endothelial inactivation of ADAM10, a key… read more here.
Keywords: adam10; endothelium; arterial endothelium; coronary arterial ... See more keywords
Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00582
Abstract: The sequential cleavage of full-length amyloid precursor protein (APP) by secretases has been at the center of efforts for understanding the onset of Alzheimer's disease (AD). A decrease in α-secretase activity was observed during the… read more here.
Keywords: adam10; secretase oxidative; extracellular signal; stress ... See more keywords
Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20160296
Abstract: By interacting directly with partner proteins and with one another, tetraspanins organize a network of interactions referred to as the tetraspanin web. ADAM10 (A Disintegrin And Metalloprotease 10), an essential membrane-anchored metalloprotease that cleaves off… read more here.
Keywords: adam10; trafficking function; metalloprotease; function metalloprotease ... See more keywords
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1744980
Abstract: ABSTRACT ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we… read more here.
Keywords: inhibitor resistance; adam10 adam17; adam17 cleave; adam10 ... See more keywords
ADAM10 inhibition improves survival and augments cardiac function after myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3640
Abstract: Following myocardial infarction (MI), adverse fibrotic remodeling with extensive deposition of extracellular matrix (ECM) components has substantial consequences for the contractility of the ventricle finally leading to terminal heart failure (HF). Recently, inhibition of ECM-remodeling… read more here.
Keywords: adam10; heart; adam10 inhibition; inhibition ... See more keywords
ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01174-2
Abstract: Background Osteosarcoma is a malignant bone tumor. Increasing evidences have revealed that a disintegrin and metalloproteinase 10 (ADAM10) is implicated in tumor development. The main purpose of this study is to explore the effects of… read more here.
Keywords: adam10; osteosarcoma; mir 122; osteosarcoma cells ... See more keywords
shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059092
Abstract: ABSTRACT RNA interference is one of the common methods of studying protein functions. In recent years critical reports have emerged indicating that off-target effects may have a much greater impact on RNAi-based analysis than previously… read more here.
Keywords: adam10 silencing; expression; cell response; adam10 ... See more keywords
Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage
Sign Up to like & getrecommendations! Published in 2021 at "Open Life Sciences"
DOI: 10.1515/biol-2021-0081
Abstract: Abstract The present research was designed to examine the effects of disintegrin metalloproteinases 10 (ADAM10) on the doxorubicin (DOX)-induced dilated cardiomyopathy (DCM) and the mechanisms involved, with a focus on ADAM10-dependent cleavage of N-cadherin. The… read more here.
Keywords: adam10; cleavage; cardiac remodeling; cadherin cleavage ... See more keywords
Ionising radiation increases permeability of endothelium through ADAM10-mediated cleavage of VE-cadherin.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18282
Abstract: The association between ionising radiation (IR) exposure and risk of cardiovascular diseases (CVD) is well documented, but the underlying mechanism is still poorly understood. As atherosclerotic plaques are the most common cause of CVD, we… read more here.
Keywords: adam10; endothelium; ionising radiation; permeability ... See more keywords
MiR-144 promotes β-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19469
Abstract: The dysregulation expression of microRNAs (miRNAs) including miR-144, has been widely documented in TBI. However, little is known about the potential roles of miR-144 in the pathogenesis of TBI. In this study, we investigated the… read more here.
Keywords: adam10; cognitive impairments; induced cognitive; amyloid accumulation ... See more keywords
Decreased expression of ADAM10 on monocytes is associated with chronic allograft dysfunction in kidney transplant recipients.
Sign Up to like & getrecommendations! Published in 2023 at "International immunopharmacology"
DOI: 10.2139/ssrn.4197799
Abstract: BACKGROUND Chronic allograft dysfunction (CAD) is a common cause of allograft loss in kidney transplant recipients (KTRs). Our previous study found that elevated serum soluble T cell immunoglobulin mucin-3 (sTim-3) was positively associated with the… read more here.
Keywords: cad; expression; mtim; allograft ... See more keywords