ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance
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DOI: 10.1080/2162402x.2020.1744980
Abstract: ABSTRACT ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we… read more here.
Keywords: inhibitor resistance; adam10 adam17; adam17 cleave; adam10 ... See more keywords
The importance of ADAM10 and ADAM17 metalloproteinases in the pathogenesis of psoriasis.
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DOI: 10.1111/ced.15239
Abstract: BACKGROUND Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation, andneoangiogenesis. The disease pathogenesis has not been fully elucidated. ADAM17 and ADAM10 are important proteases serving as regulators of inflammation. OBJECTIVES This study… read more here.
Keywords: adam17; psoriasis; adam10 adam17; pathogenesis psoriasis ... See more keywords
Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris
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DOI: 10.3389/fimmu.2022.884248
Abstract: The severe autoimmune blistering disease Pemphigus vulgaris (PV) is mainly caused by autoantibodies (IgG) against desmoglein (Dsg) 3 and Dsg1. The mechanisms leading to the development of blisters are not fully understood, but intracellular signaling… read more here.
Keywords: adhesion; inhibition; role; keratinocyte adhesion ... See more keywords
ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
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DOI: 10.3390/ijms232012621
Abstract: A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on the involvement… read more here.
Keywords: novel players; adam17 novel; players retinoblastoma; adam17 ... See more keywords