A molecular generative model of ADAM10 inhibitors by using GRU-based deep neural network and transfer learning
Sign Up to like & getrecommendations! Published in 2020 at "Chemometrics and Intelligent Laboratory Systems"
DOI: 10.1016/j.chemolab.2020.104122
Abstract: Abstract Recurrent neural network (RNN) is one of the most representative architectures in deep learning and widely adopted in many research fields especially in natural language processing. In this work, a gated-recurrent-unit (GRU)-based deep neural… read more here.
Keywords: gru based; neural network; generative model; adam10 inhibitors ... See more keywords
Inhibitors of A Disintegrin And Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect.
Sign Up to like & getrecommendations! Published in 2021 at "Haematologica"
DOI: 10.3324/haematol.2021.278469
Abstract: Shedding of A Disintegrin And Metalloproteinases (ADAM10) substrates, like TNFα or CD30, can affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. We have published two new ADAM10 inhibitors, LT4 and MN8 able to prevent… read more here.
Keywords: lymphoma; hodgkin lymphoma; disintegrin metalloproteinases; adam10 inhibitors ... See more keywords