The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03845-3
Abstract: Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17.… read more here.
Keywords: adam17; egf receptor; irhd; homology domain ... See more keywords
How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2022.01.038
Abstract: COVID-19, the respiratory infection caused by the novel coronavirus SARS-CoV-2, presents a clinical picture consistent with the dysregulation of many of the pathways mediated by the metalloprotease ADAM17. ADAM17 is a sheddase that plays a… read more here.
Keywords: sars cov; adam17; cell entry; ace2 receptor ... See more keywords
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01977-z
Abstract: The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear. This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 may ameliorate doxorubicin-induced cardiomyopathy. C57BL/6J mice were… read more here.
Keywords: mice; adam17; traf3; doxorubicin induced ... See more keywords
The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz123
Abstract: Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the… read more here.
Keywords: adam17; induced lung; tobacco smoke; cancer ... See more keywords
The importance of ADAM10 and ADAM17 metalloproteinases in the pathogenesis of psoriasis.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and experimental dermatology"
DOI: 10.1111/ced.15239
Abstract: BACKGROUND Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation, andneoangiogenesis. The disease pathogenesis has not been fully elucidated. ADAM17 and ADAM10 are important proteases serving as regulators of inflammation. OBJECTIVES This study… read more here.
Keywords: adam17; psoriasis; adam10 adam17; pathogenesis psoriasis ... See more keywords
ADAM17-Mediated Glypican-1 Shedding as a Putative Mechanism Contributing to Impaired Endothelial Shear Stress Mechanotransduction
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.2095
Abstract: Endothelial dysfunction, a hallmark of type 2 diabetes (T2D), precedes cardiovascular disease and is characterized by reduced arterial flow-mediated dilation (FMD). Typically, shear stress forces generated by blood flow are detected and transduced in an… read more here.
Keywords: shear stress; physiology; adam17; endothelial cells ... See more keywords
ADAM17 cleaves the hyaluronan receptor CD44 from the endothelial surface, leading to impaired mechanotransduction of shear stress
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.2135
Abstract: Hyaluronan is a primary component of the endothelial glycocalyx and participates in mechanotransduction of shear stress which results in vasodilation. However, extracellular hyaluronan interacts indirectly with endothelial cells via its cell surface receptor CD44, which… read more here.
Keywords: shear stress; physiology; adam17; cd44 ... See more keywords
The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/5572088
Abstract: Background A disintegrin and metalloproteinase 17 (ADAM17) is a transmembrane protein that is widely expressed in various tissues; it mediates the shedding of many membrane-bound molecules, involving cell-cell and cell-matrix interactions. We investigated the role… read more here.
Keywords: adam17; fibrosis; endoplasmic reticulum; cardiac fibrosis ... See more keywords
Abstract B57: Effect of ADAM17 inhibition on the release of IFN-y during natural killer cell-mediated antibody dependent cellular cytotoxicity in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-b57
Abstract: Introduction: Antibody-dependent cell cytotoxicity (ADCC) by NK cells is a key mechanism in the anti-cancer effects of therapeutic antibodies. CD16a is an IgG Fc receptor (FcRIII) present on the surface of NK cells and plays… read more here.
Keywords: adam17; cd16a; antibody; cancer ... See more keywords
Abstract 215: Adam17 Regulates Renal Function
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_4.215
Abstract: A disintegrin and metalloproteinase 17 (ADAM17) is a ubiquitously expressed membrane-bound sheddase that cleaves a diverse variety of membrane-bound molecules, including cytokines, growth factors, ... read more here.
Keywords: adam17; adam17 regulates; abstract 215; regulates renal ... See more keywords
Genetic polymorphism of ADAM17 and decreased bilirubin levels are associated with allergic march in the Korean population
Sign Up to like & getrecommendations! Published in 2022 at "BMC Medical Genomics"
DOI: 10.1186/s12920-022-01170-7
Abstract: Background The “allergic march” refers to changes in the frequency and intensity of allergic diseases with age. Classically, the allergic march begins with atopic dermatitis in infancy and leads to asthma and rhinitis as it… read more here.
Keywords: allergic march; bilirubin; levels associated; adam17 ... See more keywords