ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance
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DOI: 10.1080/2162402x.2020.1744980
Abstract: ABSTRACT ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we… read more here.
Keywords: inhibitor resistance; adam10 adam17; adam17 cleave; adam10 ... See more keywords