ADAM9 is present at endothelial cell - cell junctions and regulates monocyte – endothelial transmigration
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2017.09.089
Abstract: We have found that A Disintegrin And Metalloproteinase-9 (ADAM9) localises to cell-cell junctions with VE-Cadherin in confluent endothelial monolayers. Co-cultures of cells separately transfected with ADAM9-EGFP or ADAM9-HA showed expression is required in two adjacent… read more here.
Keywords: adam9; cell junctions; cell; endothelial transmigration ... See more keywords
Abstract 2130: Novel ADAM9 variant induces prostate cancer metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2130
Abstract: Prostate cancer often progresses from an androgen to castration-refractory prostate cancer and metastasizes to the bone and lymph nodes. However, there is no biomarker to predict the initiation of cancer metastasis. Therefore, it is an… read more here.
Keywords: adam9; cancer metastasis; stromal cells; prostate cancer ... See more keywords
Abstract 1116: The role of ADAM9 and PI3K-dependent NF-kappa B pathway in promoting metastasis of triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1116
Abstract: Objectives: As a zinc-dependent proteinase family member, A Disintegrin and Metalloproteinase 9 (ADAM9) has the metalloproteinase domain that performs proteolytic function to liberate or shed factors, such as bFGF, VEGF, EGF, TGF-α and IGF, from… read more here.
Keywords: pi3k dependent; cancer; breast cancer; cell ... See more keywords
Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.205393
Abstract: ABSTRACT The transmembrane protease ADAM9 is frequently upregulated in human cancers, and it promotes tumour progression in mice. In vitro, ADAM9 regulates cancer cell adhesion and migration by interacting with integrins. However, how ADAM9 modulates… read more here.
Keywords: adam9; adhesion; migration; cancer cell ... See more keywords
Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10091290
Abstract: ADAM9 is a metalloproteinase strongly expressed at the tumor-stroma border by both tumor and stromal cells. We previously showed that the host deletion of ADAM9 leads to enhanced growth of grafted B16F1 melanoma cells by… read more here.
Keywords: adam9; collagen type; expression; growth ... See more keywords