Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors.
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DOI: 10.1021/acsmedchemlett.0c00025
Abstract: We identified and explored the structure-activity-relationship (SAR) of an adamantane carboxamide chemical series of Ebola virus (EBOV) inhibitors. Selected analogs exhibited half-maximal inhibitory concentrations (EC50 values) of ∼10-15 nM in vesicular stomatitis virus (VSV) pseudotyped… read more here.
Keywords: ebola virus; discovery adamantane; adamantane carboxamides; glycoprotein ... See more keywords