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   Articles with "adamantinomatous craniopharyngioma" as a keyword



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Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review

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recommendations! Published in 2020 at "Child's Nervous System"

DOI: 10.1007/s00381-020-04677-5

Abstract: Pediatric adamantinomatous craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Arising in the sellar/suprasellar region, they grow in close proximity to critical neurological and vascular structures and can result… read more here.

Keywords: adamantinomatous craniopharyngioma; craniopharyngioma molecular; age potential; molecular age ... See more keywords

Whole exome sequencing study of adamantinomatous craniopharyngioma reveals the mutational characteristics of recurrent cases

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recommendations! Published in 2025 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-025-05061-6

Abstract: Adamantinomatous craniopharyngioma (ACP) is a benign but surgically challenging intracranial tumor, and its high postoperative recurrence rate poses a threat to patient prognosis. In this study, whole exome sequencing (WES) was performed to comprehensively understand… read more here.

Keywords: whole exome; recurrent cases; adamantinomatous craniopharyngioma; exome sequencing ... See more keywords

MODL-24. AN ORGANOTYPIC CHUNK CULTURE TECHNIQUE TO STUDY DISEASE MECHANISM AND DEVELOP TARGETED THERAPEUTICS FOR PEDIATRIC ADAMANTINOMATOUS CRANIOPHARYNGIOMA

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.597

Abstract: Abstract BACKGROUND Advances in the treatment of Adamantinomatous Craniopharyngioma (ACP) face challenges with translation to clinical study due to the absence of robust culture models of the disease. We developed a technique for culturing human… read more here.

Keywords: technique; adamantinomatous craniopharyngioma; chunk culture; targeted therapeutics ... See more keywords
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RARE-10. ADAMANTINOMATOUS CRANIOPHARYNGIOMA RESIDES OUTSIDE THE BLOOD BRAIN BARRIER

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.721

Abstract: Abstract BACKGROUND Adamantinomatous craniopharyngioma (ACP) is a devastating skull-base tumor believed to derive from epithelial remnants of the primordial craniopharyngeal duct (Rathke’s pouch), which gives rise to the anterior pituitary gland. Genetically engineered mouse models… read more here.

Keywords: adamantinomatous craniopharyngioma; blood brain; resides outside; blood ... See more keywords

CP-12. PHASE 0 AND FEASIBILITY SINGLE-INSTITUTION CLINICAL TRIAL OF INTRAVENOUS TOCILIZUMAB FOR ADAMANTINOMATOUS CRANIOPHARYNGIOMA

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.050

Abstract: Abstract BACKGROUND Adamantinomatous craniopharyngioma (ACP) is a devastating skull-base tumor believed to derive from epithelial remnants of the primordial craniopharyngeal duct (Rathke’s pouch), which gives rise to the anterior pituitary gland. ACP lacks medical antitumor… read more here.

Keywords: adamantinomatous craniopharyngioma; trial; tocilizumab; phase feasibility ... See more keywords

CD47 promotes the proliferation and migration of adamantinomatous craniopharyngioma cells by activating the MAPK/ERK pathway, and CD47 blockade facilitates microglia‐mediated phagocytosis

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recommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"

DOI: 10.1111/nan.12795

Abstract: CD47 is overexpressed in multiple tumours and plays an important role in immune escape and other biological processes of tumours. However, its role in adamantinomatous craniopharyngioma (ACP) remains unclear. Therefore, we explored the functions of… read more here.

Keywords: proliferation migration; adamantinomatous craniopharyngioma; cd47; cd47 promotes ... See more keywords

Establishment and characterisation of STAM4, a novel human adamantinomatous craniopharyngioma cell line, through human telomerase reverse transcriptase ectopic expression‐mediated immortalisation

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recommendations! Published in 2024 at "Neuropathology and Applied Neurobiology"

DOI: 10.1111/nan.12958

Abstract: Adamantinomatous craniopharyngioma (ACP) is a rare benign intracranial tumour that occurs in the sellar region and likely originates from the embryonic craniopharyngeal epithelium (a remnant of the ectoderm, also known as Rathke's pouch). However, progress… read more here.

Keywords: cell; cell line; establishment characterisation; adamantinomatous craniopharyngioma ... See more keywords

Malignancy arising in adamantinomatous craniopharyngioma: Report of a rare case with unusual morphologic features

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recommendations! Published in 2024 at "Neuropathology"

DOI: 10.1111/neup.12962

Abstract: Adamantinomatous craniopharyngioma is a grade 1 tumor that arises in a sellar/suprasellar location. Despite being a grade 1 tumor, there is high recurrence and endocrinal insufficiency. Malignancy arising in craniopharyngioma is extremely rare, has a… read more here.

Keywords: adamantinomatous craniopharyngioma; adenoid cystic; cystic carcinoma; case ... See more keywords

SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma

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recommendations! Published in 2019 at "Endocrine-Related Cancer"

DOI: 10.1530/erc-18-0538

Abstract: Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. Adamantinomatous craniopharyngioma (ACP) is a relevant pituitary tumour, affecting children and adults, that is associated with high… read more here.

Keywords: shh pathway; pathway inhibition; shh; adamantinomatous craniopharyngioma ... See more keywords

Adamantinomatous craniopharyngioma: moving toward targeted therapies.

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recommendations! Published in 2020 at "Neurosurgical focus"

DOI: 10.3171/2019.10.focus19705

Abstract: The evolving characterization of the biological basis of adamantinomatous craniopharyngioma (ACP) has provided insights critical for novel systemically delivered therapies. While current treatment strategies for ACP are associated with low mortality rates, patients experience severely… read more here.

Keywords: adamantinomatous craniopharyngioma; craniopharyngioma moving; treatment; targeted therapies ... See more keywords

Integrative Analysis of Biomarkers and Mechanisms in Adamantinomatous Craniopharyngioma

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.830793

Abstract: Craniopharyngioma is a benign tumor, and the predominant treatment methods are surgical resection and radiotherapy. However, both treatments may lead to complex complications, seriously affecting patients’ survival rate and quality of life. Adamantinomatous craniopharyngioma (ACP),… read more here.

Keywords: adamantinomatous craniopharyngioma; s100a2 sdc1; analysis; craniopharyngioma ... See more keywords