Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review
Sign Up to like & getrecommendations! Published in 2020 at "Child's Nervous System"
DOI: 10.1007/s00381-020-04677-5
Abstract: Pediatric adamantinomatous craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Arising in the sellar/suprasellar region, they grow in close proximity to critical neurological and vascular structures and can result… read more here.
Keywords: adamantinomatous craniopharyngioma; craniopharyngioma molecular; age potential; molecular age ... See more keywords
MODL-24. AN ORGANOTYPIC CHUNK CULTURE TECHNIQUE TO STUDY DISEASE MECHANISM AND DEVELOP TARGETED THERAPEUTICS FOR PEDIATRIC ADAMANTINOMATOUS CRANIOPHARYNGIOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.597
Abstract: Abstract BACKGROUND Advances in the treatment of Adamantinomatous Craniopharyngioma (ACP) face challenges with translation to clinical study due to the absence of robust culture models of the disease. We developed a technique for culturing human… read more here.
Keywords: technique; adamantinomatous craniopharyngioma; chunk culture; targeted therapeutics ... See more keywords
RARE-10. ADAMANTINOMATOUS CRANIOPHARYNGIOMA RESIDES OUTSIDE THE BLOOD BRAIN BARRIER
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.721
Abstract: Abstract BACKGROUND Adamantinomatous craniopharyngioma (ACP) is a devastating skull-base tumor believed to derive from epithelial remnants of the primordial craniopharyngeal duct (Rathke’s pouch), which gives rise to the anterior pituitary gland. Genetically engineered mouse models… read more here.
Keywords: adamantinomatous craniopharyngioma; blood brain; resides outside; blood ... See more keywords
CD47 promotes the proliferation and migration of adamantinomatous craniopharyngioma cells by activating the MAPK/ERK pathway, and CD47 blockade facilitates microglia‐mediated phagocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12795
Abstract: CD47 is overexpressed in multiple tumours and plays an important role in immune escape and other biological processes of tumours. However, its role in adamantinomatous craniopharyngioma (ACP) remains unclear. Therefore, we explored the functions of… read more here.
Keywords: proliferation migration; adamantinomatous craniopharyngioma; cd47; cd47 promotes ... See more keywords
SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-18-0538
Abstract: Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. Adamantinomatous craniopharyngioma (ACP) is a relevant pituitary tumour, affecting children and adults, that is associated with high… read more here.
Keywords: shh pathway; pathway inhibition; shh; adamantinomatous craniopharyngioma ... See more keywords
Adamantinomatous craniopharyngioma: moving toward targeted therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Neurosurgical focus"
DOI: 10.3171/2019.10.focus19705
Abstract: The evolving characterization of the biological basis of adamantinomatous craniopharyngioma (ACP) has provided insights critical for novel systemically delivered therapies. While current treatment strategies for ACP are associated with low mortality rates, patients experience severely… read more here.
Keywords: adamantinomatous craniopharyngioma; craniopharyngioma moving; treatment; targeted therapies ... See more keywords
Integrative Analysis of Biomarkers and Mechanisms in Adamantinomatous Craniopharyngioma
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DOI: 10.3389/fgene.2022.830793
Abstract: Craniopharyngioma is a benign tumor, and the predominant treatment methods are surgical resection and radiotherapy. However, both treatments may lead to complex complications, seriously affecting patients’ survival rate and quality of life. Adamantinomatous craniopharyngioma (ACP),… read more here.
Keywords: adamantinomatous craniopharyngioma; s100a2 sdc1; analysis; craniopharyngioma ... See more keywords
Integrative analyses identify HIF-1α as a potential protective role with immune cell infiltration in adamantinomatous craniopharyngioma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.949509
Abstract: Craniopharyngiomas (CPs) are histologically benign tumors located in the sellar–suprasellar region. Although the transcriptome development in recent years have deepened our knowledge to the tumorigenesis process of adamantinomatous craniopharyngioma (ACP), the peritumoral immune infiltration of… read more here.
Keywords: infiltration; cell infiltration; immune cell; adamantinomatous craniopharyngioma ... See more keywords
Bioinformatics analysis and validation of the critical genes associated with adamantinomatous craniopharyngioma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1007236
Abstract: Adamantinomatous craniopharyngioma (ACP) is an epithelial tumor that arises when Rathke’s pouch remains during embryonic development. The pathogenesis of ACP remains unclear, and treatment options are limited. Here, we reveal the critical genes expressed in… read more here.
Keywords: critical genes; bioinformatics analysis; adamantinomatous craniopharyngioma; analysis ... See more keywords
Uncertainty-Aware Deep Learning Classification of Adamantinomatous Craniopharyngioma from Preoperative MRI
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13061132
Abstract: Diagnosis of adamantinomatous craniopharyngioma (ACP) is predominantly determined through invasive pathological examination of a neurosurgical biopsy specimen. Clinical experts can distinguish ACP from Magnetic Resonance Imaging (MRI) with an accuracy of 86%, and 9% of… read more here.
Keywords: preoperative mri; classification; uncertainty; adamantinomatous craniopharyngioma ... See more keywords