ADAMTS-6 is a predictor of poor prognosis in patients with esophageal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2018.02.004
Abstract: BACKGROUND A disintegrin and metalloprotease with thrombospondin motif (ADAMTS) enzymes play important roles in cell functions including adhesion, invasion, migration, and proliferation. ADAMTS-6 is a member of the ADAMTS family; reports of its relationship with… read more here.
Keywords: prognosis; squamous cell; adamts expression; expression ... See more keywords
ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07340-3
Abstract: Von Willebrand factor (VWF) is secreted as an acute phase protein during inflammation. ADAMTS-13 regulates the size and prothrombotic activity of VWF by it’s specific proteolytic activity. To determine the relevance of this regulatory pathway… read more here.
Keywords: model invasive; invasive pulmonary; mice; adamts ... See more keywords
ADAMTS‐13 and von Willebrand factor: a dynamic duo
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13898
Abstract: von Willebrand factor (VWF) is a key player in hemostasis, acting as a carrier for factor VIII and capturing platelets at sites of vascular damage. To capture platelets, it must undergo conformational changes, both within… read more here.
Keywords: factor; willebrand factor; von willebrand; adamts ... See more keywords
A human monoclonal antibody against the distal carboxyl terminus of ADAMTS‐13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15332
Abstract: Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS‐13 (A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif, member 13) activity. IgG‐type autoantibodies are primarily… read more here.
Keywords: human monoclonal; thrombotic thrombocytopenic; adamts; thrombocytopenic purpura ... See more keywords
Sustained VWF‐ADAMTS‐13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15830
Abstract: Prolonged recovery is common after acute SARS‐CoV‐2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS‐13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute COVID‐19. We hypothesized that VWF/ADAMTS‐13 imbalance persists… read more here.
Keywords: vwf adamts; adamts; long covid; imbalance ... See more keywords
Abstract 81: Endogenous ADAMTS-13 regulates vasculogenic functions in glioblastoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-81
Abstract: ADAMTS-13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13, is a zinc-containing metalloprotease that cleaves von Willebrand factor. Previous publications by our laboratory have shown that either endogenous or exogenous ADAMTS-13… read more here.
Keywords: endogenous adamts; functions glioblastoma; adamts; vasculogenic functions ... See more keywords
Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.122.061516
Abstract: Background: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with thrombospondin type 1 motif 7) is a novel locus associated with human coronary atherosclerosis. ADAMTS-7 deletion protects against atherosclerosis and vascular restenosis in rodents. Methods: We… read more here.
Keywords: vaccine adamts; adamts; adamts ameliorates; peptide vaccine ... See more keywords
Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-06-788026
Abstract: Safety, tolerability, and pharmacokinetics of recombinant ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; BAX 930; SHP655) were investigated in 15 patients diagnosed with severe congenital ADAMTS-13 deficiency (plasma ADAMTS-13… read more here.
Keywords: adamts; bax 930; recombinant adamts; safety ... See more keywords
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2020.00136
Abstract: Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling. Recently, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5 (ADAMTS-5) has been reported… read more here.
Keywords: plasma; apoptosis; aortic dissection; smooth muscle ... See more keywords
Regulation of ADAMTS Proteases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.701959
Abstract: A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases are secreted metalloproteinases that play key roles in the formation, homeostasis and remodeling of the extracellular matrix (ECM). The substrate spectrum of ADAMTS proteases… read more here.
Keywords: adamts; regulation adamts; ecm; adamts proteases ... See more keywords
First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12030648
Abstract: Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients. Methods: Native kidney (NKB) and kidney transplant (TXCI) biopsy samples as well as plasma… read more here.
Keywords: potential novel; novel diagnostic; adamts; kidney ... See more keywords