Preemptive cyclosporin A in immune‐mediated thrombotic thrombocytopenic purpura
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Haematology"
DOI: 10.1111/ejh.13886
Abstract: Survivors of immune‐mediated thrombotic thrombocytopenic purpura (iTTP) are exposed to clinical relapses when a disintegrin and metalloproteinase with thrombospondin type 1 repeats, member 13 (ADAMTS13) activity decreases during follow‐up. Although preemptive rituximab usually improves ADAMTS13… read more here.
Keywords: mediated thrombotic; immune mediated; activity; thrombotic thrombocytopenic ... See more keywords
A multicenter evaluation of the Technoscreen ADAMTS13 activity semi-quantitative screening test for thrombotic thrombocytopenic purpura diagnosis and exclusion.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14077
Abstract: INTRODUCTION Thrombotic thrombocytopenic purpura (TTP) is a rare but potentially fatal microangiopathy, with an untreated mortality rate of around 90%. TTP is caused by severe deficiency in ADAMTS13, which results in accumulation of ultra large… read more here.
Keywords: adamts13; test; activity; thrombotic thrombocytopenic ... See more keywords
Platelet Count, ADAMTS13 Activity, von Willebrand Factor Level and Survival in Patients with Colorectal Cancer: 5-Year Follow-up Study.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1160/th17-07-0548
Abstract: Distant metastasis is a major cause of colorectal cancer-related death, but the mechanism of tumour progression is not fully understood. There is growing evidence of an interaction between tumour cells and platelets which may influence… read more here.
Keywords: platelet count; colorectal cancer; platelet; adamts13 activity ... See more keywords
Disruption of ADAMTS13-Autoantibody Complexes with an ADAMTS13 Spacer Domain As a Potential Therapeutic Strategy for Immune Thrombotic Thrombocytopenic Purpura
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DOI: 10.1182/blood-2019-125965
Abstract: Background: Immune thrombotic thrombocytopenic purpura (iTTP) is primarily caused by acquired immunoglobulin (Ig) G against ADAMTS13, a member of the A Disintegrin and Metalloprotease with Thrombospondin Type 1 repeats family, which specifically cleaves von Willebrand… read more here.
Keywords: spacer domain; spacer; adamts13 activity;
Recognizing Hereditary TTP in Infants and Children
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DOI: 10.1182/blood-2020-133918
Abstract: Recognition of hereditary disorders in newborn infants and early childhood is critical for anticipating and preventing adverse outcomes. Hereditary thrombotic thrombocytopenic purpura (HTTP) is caused by biallelicADAMTS13mutations. Absence of ADAMTS13 results in circulation of ultra-large… read more here.
Keywords: diagnosis; age; adamts13 activity; http ... See more keywords
Comparative Analysis of Clinical Prediction Scores in Acquired Thrombotic Thrombocytopenic Purpura: The Superiority of Plasmic Score
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DOI: 10.1182/blood-2020-143159
Abstract: Background: Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare and life-threatening hematologic disorder. The decision to start plasma exchange is challenging in clinical practice, due to aTTP rarity, and the extensive differential diagnosis with other… read more here.
Keywords: adamts13 activity; score; french score; plasmic score ... See more keywords