ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101472
Abstract: Summary ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are secreted metalloproteinases that play a major role in the assembly and degradation of the extracellular matrix (ECM). In this study, we show that ADAMTS18, produced… read more here.
Keywords: deficiency leads; microfibril accumulation; adamts18; adamts18 deficiency ... See more keywords
Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dental research"
DOI: 10.1177/00220345211029270
Abstract: Chronic sclerosing sialadenitis of the submandibular gland (also known as Küttner tumor) is characterized by concomitant swelling of the submandibular glands secondary to strong lymphocytic infiltration and fibrosis. The pathogenesis of this disease has been… read more here.
Keywords: smg; adult; adamts18 mice; mice ... See more keywords
Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14866
Abstract: ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not clear. Here we generated an Adamts18-deficient mouse strain as an in vivo model… read more here.
Keywords: p38mapk erk1; colorectal cancer; cancer; adamts18 deficiency ... See more keywords