Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide
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DOI: 10.1038/s41598-021-93663-1
Abstract: The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). We hypothesized… read more here.
Keywords: adaptation human; transcription factor; activating transcription; glioblastoma cells ... See more keywords
Past and ongoing adaptation of human cytomegalovirus to its host
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DOI: 10.1371/journal.ppat.1008476
Abstract: Cytomegaloviruses (order Herpesvirales) display remarkable species-specificity as a result of long-term co-evolution with their mammalian hosts. Human cytomegalovirus (HCMV) is exquisitely adapted to our species and displays high genetic diversity. We leveraged information on inter-species… read more here.
Keywords: diversity; adaptation human; human cytomegalovirus; host ... See more keywords