LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy.
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DOI: 10.1101/gr.265017.120
Abstract: Somatic motor neurons are selectively vulnerable in spinal muscular atrophy (SMA), which is caused by a deficiency of the ubiquitously expressed survival of motor neuron protein. However, some motor neuron groups, including oculomotor and trochlear… read more here.
Keywords: motor neurons; spinal muscular; motor; muscular atrophy ... See more keywords
Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability
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DOI: 10.1371/journal.pcbi.1010833
Abstract: Tumours are subject to external environmental variability. However, in vitro tumour spheroid experiments, used to understand cancer progression and develop cancer therapies, have been routinely performed for the past fifty years in constant external environments.… read more here.
Keywords: spheroids time; time dependent; growth; oxygen ... See more keywords
Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells
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DOI: 10.3390/genes13122368
Abstract: This study aimed to establish the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways using K562 cells induced to… read more here.
Keywords: k562 cells; expression; gene expression; adaptation mechanisms ... See more keywords
Dissecting Adaptation Mechanisms to Contrasting Solar Irradiance in the Mediterranean Shrub Cistus incanus
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DOI: 10.3390/ijms20143599
Abstract: Molecular mechanisms that are the base of the strategies adopted by Mediterranean plants to cope with the challenges imposed by limited or excessive solar radiation during the summer season have received limited attention. In our… read more here.
Keywords: mechanisms contrasting; solar irradiance; contrasting solar; adaptation mechanisms ... See more keywords
Modulation of neuronal dynamic range using two different adaptation mechanisms
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DOI: 10.4103/1673-5374.202931
Abstract: The capability of neurons to discriminate between intensity of external stimulus is measured by its dynamic range. A larger dynamic range indicates a greater probability of neuronal survival. In this study, the potential roles of… read more here.
Keywords: range; dynamic range; different adaptation; neuronal dynamic ... See more keywords