Information-adaptive clinical trials with selective recruitment and binary outcomes.
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DOI: 10.1002/sim.7353
Abstract: Selective recruitment designs preferentially recruit individuals who are estimated to be statistically informative onto a clinical trial. Individuals who are expected to contribute less information have a lower probability of recruitment. Furthermore, in an information-adaptive… read more here.
Keywords: selective recruitment; information; recruitment; adaptive clinical ... See more keywords
Inference in response-adaptive clinical trials when the enrolled population varies over time.
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DOI: 10.1111/biom.13582
Abstract: A common assumption of data analysis in clinical trials is that the patient population, as well as treatment effects, do not vary during the course of the study. However, when trials enroll patients over several… read more here.
Keywords: time; adaptive clinical; clinical trials; response adaptive ... See more keywords
How can health economics be used in the design and analysis of adaptive clinical trials? A qualitative analysis
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DOI: 10.1186/s13063-020-4137-2
Abstract: Introduction Adaptive designs offer a flexible approach, allowing changes to a trial based on examinations of the data as it progresses. Adaptive clinical trials are becoming a popular choice, as the prudent use of finite… read more here.
Keywords: health economics; analysis; adaptive clinical; clinical trials ... See more keywords
Critical concepts in adaptive clinical trials
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DOI: 10.2147/clep.s156708
Abstract: Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade… read more here.
Keywords: adaptive designs; concepts adaptive; adaptive clinical; clinical trials ... See more keywords
Arguing for Adaptive Clinical Trials in Sepsis
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DOI: 10.3389/fimmu.2018.01502
Abstract: Sepsis is life-threatening organ dysfunction due to dysregulated response to infection. Patients with sepsis exhibit wide heterogeneity stemming from genetic, molecular, and clinical factors as well as differences in pathogens, creating challenges for the development… read more here.
Keywords: sepsis; trial; trials sepsis; adaptive clinical ... See more keywords
The Bayesian Design of Adaptive Clinical Trials
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DOI: 10.3390/ijerph18020530
Abstract: This paper presents a brief overview of the recent literature on adaptive design of clinical trials from a Bayesian perspective for statistically not so sophisticated readers. Adaptive designs are attracting a keen interest in several… read more here.
Keywords: design adaptive; adaptive clinical; clinical trials; bayesian design ... See more keywords