A practical Bayesian adaptive design incorporating data from historical controls.
Sign Up to like & getrecommendations! Published in 2018 at "Statistics in medicine"
DOI: 10.1002/sim.7897
Abstract: In this paper, we develop the fixed-borrowing adaptive design, a Bayesian adaptive design which facilitates information borrowing from a historical trial using subject-level control data while assuring a reasonable upper bound on the maximum type… read more here.
Keywords: methodology; trial; analysis; bayesian adaptive ... See more keywords
An adaptive design approach for defects distribution modeling in materials from first-principle calculations
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-020-04438-w
Abstract: Designing and understanding the mechanism of non-stoichiometric materials with enhanced properties is challenging, both experimentally and even computationally, due to the large number of chemical spaces and their distributions through the material. In the current… read more here.
Keywords: principle calculations; first principle; materials first; approach ... See more keywords
Extensions of the 2-in-1 adaptive design.
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2020.106053
Abstract: The 2-in-1 adaptive design [Chen et al. 2018] allows seamless expansion of an ongoing Phase 2 trial into a Phase 3 trial to expedite a drug development program. An intermediate endpoint can be used for… read more here.
Keywords: phase trial; expansion; adaptive design; design ... See more keywords
A two-stage Bayesian adaptive design for minimum effective dose (MinED)-based dosing-finding trials.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106504
Abstract: Conventional phase I designs for finding a phase II recommended dose (P2RD) based on toxicity alone is problematic because the maximum tolerated dose (MTD) is not necessarily the optimal dose. Instead, recently attention has been… read more here.
Keywords: two stage; dose mined; minimum effective; effective dose ... See more keywords
Adaptive design of experiments based on Gaussian mixture regression
Sign Up to like & getrecommendations! Published in 2021 at "Chemometrics and Intelligent Laboratory Systems"
DOI: 10.1016/j.chemolab.2020.104226
Abstract: Abstract In the design of molecules, materials, and processes, adaptive design of experiments (ADoE) is conducted to minimize the number of experiments. Although Bayesian optimization (BO) is an effective tool, BO merely selects a candidate… read more here.
Keywords: number; mixture regression; gaussian mixture; design experiments ... See more keywords
A Bayesian adaptive design for cancer phase I trials using a flexible range of doses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1372774
Abstract: ABSTRACT We present a Bayesian adaptive design for dose finding in cancer phase I clinical trials. The goal is to estimate the maximum tolerated dose (MTD) after possible modification of the dose range during the… read more here.
Keywords: trial; range doses; bayesian adaptive; adaptive design ... See more keywords
Adaptive design methods in dialysis clinical trials: a systematic review protocol
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open"
DOI: 10.1136/bmjopen-2019-036755
Abstract: Introduction Adaptive design methods are a potential solution to improve efficiency of clinical trials but their uptake in dialysis is unknown. We aim to investigate the use of adaptive design methods in dialysis clinical trials… read more here.
Keywords: methods dialysis; design methods; clinical trials; dialysis ... See more keywords
Bayesian order constrained adaptive design for phase II clinical trials evaluating subgroup-specific treatment effect.
Sign Up to like & getrecommendations! Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231158738
Abstract: The “one-size-fits-all’’ paradigm is inappropriate for phase II clinical trials evaluating biotherapies, which are often expected to have substantial heterogeneous treatment effects among different subgroups defined by biomarker. For these biotherapies, the objective of phase… read more here.
Keywords: adaptive design; bayesian order; design; constrained adaptive ... See more keywords
A Bayesian adaptive design for clinical trials of rare efficacy outcomes with multiple definitions
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DOI: 10.1177/17407745221118366
Abstract: Introduction: Bayesian adaptive designs for clinical trials have gained popularity in the recent years due to the flexibility and efficiency that they offer. We consider the scenario where the outcome of interest comprises events with… read more here.
Keywords: clinical trials; adaptive design; bayesian adaptive; trials rare ... See more keywords
[How to report adaptive design randomized trials-A interpretation of international reporting guideline ACE].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi"
DOI: 10.3760/cma.j.cn112338-20210319-00230
Abstract: Concerns has been raised in improving the quality of adaptive design randomized trials reports. Based on the CONSORT 2010 (Consolidated Standards of Reporting Trials), The Adaptive designs CONSORT Extension (ACE) has developed items and reporting… read more here.
Keywords: report adaptive; adaptive design; ace; design ... See more keywords