Opportunity for efficiency in clinical development: An overview of adaptive clinical trial designs and innovative machine learning tools, with examples from the cardiovascular field.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106397
Abstract: Modern data analysis tools and statistical modeling techniques are increasingly used in clinical research to improve diagnosis, estimate disease progression and predict treatment outcomes. What seems less emphasized is the importance of the study design,… read more here.
Keywords: adaptive designs; efficiency; machine learning; trial designs ... See more keywords
Multi-arm response-adaptive designs for circular responses
Sign Up to like & getrecommendations! Published in 2019 at "Journal of The Korean Statistical Society"
DOI: 10.1016/j.jkss.2019.03.005
Abstract: Abstract A multi-arm response-adaptive allocation design is developed for circular treatment outcomes. Several exact and asymptotic properties of the design are studied. Stage-wise treatment selection procedures based on the proposed response-adaptive design are also suggested… read more here.
Keywords: response; designs circular; response adaptive; arm response ... See more keywords
An early-stage analysis of climate-adaptive designs for multi-family buildings under future climate scenario: Case studies in Rome, Italy and Stockholm, Sweden
Sign Up to like & getrecommendations! Published in 2020 at "Journal of building engineering"
DOI: 10.1016/j.jobe.2019.100972
Abstract: Abstract This paper presents a preliminary case study of climate-adaptive designs for urban multi-family buildings at early stage, to allow thermal comfort and minimum energy use from today to the last part of 21st century.… read more here.
Keywords: multi family; adaptive designs; climate adaptive; climate ... See more keywords
Tests and classification methods in adaptive designs with applications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Statistics"
DOI: 10.1080/02664763.2022.2026898
Abstract: Statistical tests for biomarker identification and classification methods for patient grouping are two important topics in adaptive designs of clinical trials related to genomic studies. In this article, we evaluate four test methods for biomarker… read more here.
Keywords: classification methods; methods adaptive; identification; adaptive designs ... See more keywords
A general strategy for reducing the variability in response-adaptive designs
Sign Up to like & getrecommendations! Published in 2024 at "Communications in Statistics - Theory and Methods"
DOI: 10.1080/03610926.2024.2408576
Abstract: Abstract. Adaptive designs for clinical trials address the ethical requirement of allocating fewer patients to the inferior treatment as the trial progresses. We present here a generic strategy partly motivated by play-the-winner heuristic for reducing… read more here.
Keywords: reducing variability; response adaptive; adaptive designs; strategy ... See more keywords
Interim decision-making strategies in adaptive designs for population selection using time-to-event endpoints
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2016.1148714
Abstract: ABSTRACT Adaptive designs in oncology clinical trials with interim analyses for population selection could be used in the development of targeted therapies if a predefined biomarker hypothesis exists. In this article, we consider an interim… read more here.
Keywords: decision; population selection; adaptive designs; decision making ... See more keywords
Bayesian response-adaptive designs for basket trials.
Sign Up to like & getrecommendations! Published in 2017 at "Biometrics"
DOI: 10.1111/biom.12668
Abstract: We develop a general class of response-adaptive Bayesian designs using hierarchical models, and provide open source software to implement them. Our work is motivated by recent master protocols in oncology, where several treatments are investigated… read more here.
Keywords: designs basket; bayesian response; adaptive designs; response adaptive ... See more keywords
Promising zone two-stage design for a single-arm study with binary outcome.
Sign Up to like & getrecommendations! Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231164737
Abstract: Adaptive designs are increasingly used in clinical trials to assess the effectiveness of new drugs. For a single-arm study with a binary outcome, several adaptive designs were developed by using numerical search algorithms and the… read more here.
Keywords: study binary; single arm; adaptive designs; design ... See more keywords
Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study.
Sign Up to like & getrecommendations! Published in 2025 at "BMC medical research methodology"
DOI: 10.1186/s12874-025-02730-y
Abstract: Trials that aim to optimise the implementation of an intervention are often complex, requiring multiple, combined strategies and requiring uptake on multiple levels. Previous implementation trials have optimised implementation strategies using multi-arm cluster randomised control… read more here.
Keywords: optimise implementation; trial; implementation strategies; implementation ... See more keywords
Critical concepts in adaptive clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Epidemiology"
DOI: 10.2147/clep.s156708
Abstract: Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade… read more here.
Keywords: adaptive designs; concepts adaptive; adaptive clinical; clinical trials ... See more keywords
The critical need to accelerate cerebral palsy research with consumer engagement, global networks, and adaptive designs
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pediatric Rehabilitation Medicine"
DOI: 10.3233/prm-240014
Abstract: The prevalence of cerebral palsy (CP) varies globally, with higher rates and burden of disease in low- and middle-income countries. CP is a lifelong condition with no cure, presenting diverse challenges such as motor impairment,… read more here.
Keywords: consumer engagement; consumer; engagement global; research ... See more keywords