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Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106397
Abstract: Modern data analysis tools and statistical modeling techniques are increasingly used in clinical research to improve diagnosis, estimate disease progression and predict treatment outcomes. What seems less emphasized is the importance of the study design,…
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Keywords:
adaptive designs;
efficiency;
machine learning;
trial designs ... See more keywords
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Published in 2019 at "Journal of The Korean Statistical Society"
DOI: 10.1016/j.jkss.2019.03.005
Abstract: Abstract A multi-arm response-adaptive allocation design is developed for circular treatment outcomes. Several exact and asymptotic properties of the design are studied. Stage-wise treatment selection procedures based on the proposed response-adaptive design are also suggested…
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Keywords:
response;
designs circular;
response adaptive;
arm response ... See more keywords
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Published in 2020 at "Journal of building engineering"
DOI: 10.1016/j.jobe.2019.100972
Abstract: Abstract This paper presents a preliminary case study of climate-adaptive designs for urban multi-family buildings at early stage, to allow thermal comfort and minimum energy use from today to the last part of 21st century.…
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Keywords:
multi family;
adaptive designs;
climate adaptive;
climate ... See more keywords
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Published in 2022 at "Journal of Applied Statistics"
DOI: 10.1080/02664763.2022.2026898
Abstract: Statistical tests for biomarker identification and classification methods for patient grouping are two important topics in adaptive designs of clinical trials related to genomic studies. In this article, we evaluate four test methods for biomarker…
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Keywords:
classification methods;
methods adaptive;
identification;
adaptive designs ... See more keywords
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Published in 2017 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2016.1148714
Abstract: ABSTRACT Adaptive designs in oncology clinical trials with interim analyses for population selection could be used in the development of targeted therapies if a predefined biomarker hypothesis exists. In this article, we consider an interim…
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Keywords:
decision;
population selection;
adaptive designs;
decision making ... See more keywords
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Published in 2017 at "Biometrics"
DOI: 10.1111/biom.12668
Abstract: We develop a general class of response-adaptive Bayesian designs using hierarchical models, and provide open source software to implement them. Our work is motivated by recent master protocols in oncology, where several treatments are investigated…
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Keywords:
designs basket;
bayesian response;
adaptive designs;
response adaptive ... See more keywords
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Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231164737
Abstract: Adaptive designs are increasingly used in clinical trials to assess the effectiveness of new drugs. For a single-arm study with a binary outcome, several adaptive designs were developed by using numerical search algorithms and the…
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Keywords:
study binary;
single arm;
adaptive designs;
design ... See more keywords
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Published in 2018 at "Clinical Epidemiology"
DOI: 10.2147/clep.s156708
Abstract: Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade…
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Keywords:
adaptive designs;
concepts adaptive;
adaptive clinical;
clinical trials ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061566
Abstract: Simple Summary Phase I cancer trials are important for new drug developments to test the safety and optimal dosage of cancer drugs which are usually toxic. Understanding biostatistical methodologies of these designs is important for…
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Keywords:
brief overview;
cancer trials;
adaptive designs;
phase cancer ... See more keywords