Optimized adaptive enrichment designs for three-arm trials: learning which subpopulations benefit from different treatments.
Sign Up to like & getrecommendations! Published in 2019 at "Biostatistics"
DOI: 10.1093/biostatistics/kxz030
Abstract: We consider the problem of designing a confirmatory randomized trial for comparing two treatments versus a common control in two disjoint subpopulations. The subpopulations could be defined in terms of a biomarker or disease severity… read more here.
Keywords: enrichment designs; design; adaptive enrichment; trial ... See more keywords
Rejoinder to discussion on “Adaptive enrichment designs with a continuous biomarker”
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13639
Abstract: I am grateful to the editors for inviting a discussion of my article, and to the discussants for their many thoughtful and stimulating comments on the work and suggestions for how it may be extended.… read more here.
Keywords: rejoinder discussion; biomarker; enrichment designs; discussion adaptive ... See more keywords
Tappas: An adaptive enrichment phase 3 trial of TRC105 and pazopanib versus pazopanib alone in patients with advanced angiosarcoma (AAS).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.tps11081
Abstract: TPS11081Background: AAS is an aggressive soft tissue sarcoma (STS) of endothelial cell origin with an expected median overall survival of 8-12 months. Pazopanib (P) is approved for treatment of adv... read more here.
Keywords: pazopanib; tappas adaptive; adaptive enrichment; trial trc105 ... See more keywords