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Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.6910
Abstract: There has been constant development of novel statistical methods in the design of early-phase clinical trials since the introduction of model-based designs, yet the traditional or modified 3+3 algorithmic design remains the most widely used…
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Keywords:
early phase;
clinical trials;
implementation adaptive;
phase clinical ... See more keywords
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Published in 2019 at "Applied Mathematical Modelling"
DOI: 10.1016/j.apm.2018.09.028
Abstract: Abstract The trend of applying mathematical foundations of fractional calculus to solve problems arising in nonlinear sciences, is an emerging area of research with growing interest especially in communication, signal analysis and control. In the…
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Keywords:
nonlinear control;
methods nonlinear;
adaptive methods;
fractional adaptive ... See more keywords
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Published in 2020 at "Spinal cord"
DOI: 10.1038/s41393-020-00547-8
Abstract: STUDY DESIGN Narrative review. PURPOSE To provide an overview of adaptive trial designs, and describe how adaptive methods can address persistent challenges encountered by randomized controlled trials of people with spinal cord injury (SCI). RESULTS…
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Keywords:
adaptive trial;
trial;
trial designs;
adaptive methods ... See more keywords
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Published in 2019 at "Tourism Geographies"
DOI: 10.1080/14616688.2019.1682653
Abstract: Abstract Around the world the twenty-first century has seen growth in the number and scale of protest events, mobilising substantial numbers of people to gather in acts of dissent. Central to understanding participation in such…
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Keywords:
tourism;
activist tourism;
imaginaries dissent;
film ... See more keywords
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Published in 2020 at "Solar System Research"
DOI: 10.1134/s0038094620040061
Abstract: Abstract — We consider space expeditions with a long-term spacecraft stay near the studied celestial body (artificial satellites of small bodies of the Solar System), or expeditions with a possible spacecraft landing on the surface…
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Keywords:
jovian system;
system;
adaptive methods;
methods flybys ... See more keywords