A multi-source adaptive platform design for testing sequential combinatorial therapeutic strategies.
Sign Up to like & getrecommendations! Published in 2018 at "Biometrics"
DOI: 10.1111/biom.12841
Abstract: Traditional paradigms for clinical translation are challenged in settings where multiple contemporaneous therapeutic strategies have been identified as potentially beneficial. Platform trials have emerged as an approach for sequentially comparing multiple trials using a single… read more here.
Keywords: multi source; therapeutic strategies; adaptive platform; platform ... See more keywords
Patient and caregiver perspectives on the design and execution of ACT-GLOBAL, a stroke adaptive platform trial: a focus group study.
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DOI: 10.1159/000546132
Abstract: Abstract Introduction: Adaptive platform trials represent a paradigm shift in stroke research. We examined how patient-partners perceived the design and execution of an international platform trial in acute stroke, ACT-GLOBAL (A multi-faCtorial, mulTi-arm, multi-staGe, randomized,… read more here.
Keywords: focus; stroke; adaptive platform; platform trial ... See more keywords
Adaptive Platform Trials in Stroke.
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DOI: 10.1161/strokeaha.124.045754
Abstract: Clinical trials of treatments for stroke have generally utilized 2-arm, randomized designs to evaluate a single intervention against a control. Running separate clinical trials, with each addressing a single therapeutic question, is resource intensive and… read more here.
Keywords: adaptive platform; platform trials; clinical trials; platform ... See more keywords
This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols
Sign Up to like & getrecommendations! Published in 2019 at "Trials"
DOI: 10.1186/s13063-019-3216-8
Abstract: BackgroundThere are limited research and literature on the trial management challenges encountered in running adaptive platform trials. This trial design allows both (1) the seamless addition of new research comparisons when compelling clinical and scientific… read more here.
Keywords: trial management; adaptive platform; trial; research comparisons ... See more keywords
Adaptive, platform trials assessing therapies for hospitalized COVID-19 patients: Informed consent forms omitted a few important elements of information
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DOI: 10.7189/jogh.13.06019
Abstract: Background The information provided to participants of adaptive platform trials assessing therapies for COVID-19 inpatients is unknown. We aim to evaluate it by reviewing participant information sheets/informed consent forms (PIS/ICFs). Methods We searched the Cochrane… read more here.
Keywords: information; pis icfs; platform trials; elements information ... See more keywords
Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)
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DOI: 10.7554/elife.83201
Abstract: Background: There is no generally accepted methodology for in vivo assessment of antiviral activity in SARS-CoV-2 infections. Ivermectin has been recommended widely as a treatment of COVID-19, but whether it has clinically significant antiviral activity… read more here.
Keywords: platform trial; trial; covid; high dose ... See more keywords