Group Response‐Adaptive Randomization With Delayed and Missing Responses
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DOI: 10.1002/sim.10220
Abstract: Response‐adaptive randomization (RAR) procedures have been extensively studied in the literature, but most of the procedures rely on updating the randomization after each response, which is impractical in many clinical trials. In this article, we… read more here.
Keywords: adaptive randomization; response adaptive; response; group ... See more keywords
Response‐Adaptive Randomization Procedure in Clinical Trials with Surrogate Endpoints
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DOI: 10.1002/sim.10286
Abstract: In clinical trials, subjects are usually recruited sequentially. According to the outcomes amassed thus far in a trial, the response‐adaptive randomization (RAR) design has been shown to be an advantageous treatment assignment procedure that skews… read more here.
Keywords: adaptive randomization; response adaptive; procedure; surrogate endpoints ... See more keywords
Statistical inference for response adaptive randomization procedures with adjusted optimal allocation proportions
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DOI: 10.1080/10543406.2016.1269780
Abstract: ABSTRACT Seamless phase II/III clinical trials have attracted increasing attention recently. They mainly use Bayesian response adaptive randomization (RAR) designs. There has been little research into seamless clinical trials using frequentist RAR designs because of… read more here.
Keywords: response adaptive; allocation proportions; statistical inference; adaptive randomization ... See more keywords
Robustness of response-adaptive randomization.
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DOI: 10.1093/biomtc/ujae049
Abstract: Doubly adaptive biased coin design (DBCD), a response-adaptive randomization scheme, aims to skew subject assignment probabilities based on accrued responses for ethical considerations. Recent years have seen substantial advances in understanding DBCD's theoretical properties, assuming… read more here.
Keywords: adaptive randomization; response adaptive; model; model misspecification ... See more keywords
Statistical inference on the relative risk following covariate-adaptive randomization.
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DOI: 10.1093/biomtc/ujaf036
Abstract: Covariate-adaptive randomization (CAR) is widely adopted in clinical trials to ensure balanced treatment allocations across key baseline covariates. Although much research has focused on analyzing average treatment effects, the inference of relative risk under CAR… read more here.
Keywords: adaptive randomization; risk; covariate adaptive; relative risk ... See more keywords
An alternative metric for evaluating the potential patient benefit of response-adaptive randomization procedures.
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DOI: 10.1111/biom.13673
Abstract: When planning a two-arm group sequential clinical trial with a binary primary outcome that has severe implications for quality of life (e.g., mortality), investigators may strive to find the design that maximizes in-trial patient benefit.… read more here.
Keywords: adaptive randomization; response adaptive; patient benefit; trial ... See more keywords
Familywise error rate control for block response-adaptive randomization.
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DOI: 10.1177/09622802231167437
Abstract: Response-adaptive randomization allows the probabilities of allocating patients to treatments in a clinical trial to change based on the previously observed response data, in order to achieve different experimental goals. One concern over the use… read more here.
Keywords: adaptive randomization; response adaptive; error rate; response ... See more keywords
Covariate selection for optimizing balance with an innovative adaptive randomization approach
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DOI: 10.1177/09622802241313283
Abstract: Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline covariates is large. It… read more here.
Keywords: randomization approach; balance; covariate selection; adaptive randomization ... See more keywords
Time trends with response-adaptive randomization: The inevitability of inefficiency
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DOI: 10.1177/17407745211065762
Abstract: Response-adaptive randomization, which changes the randomization ratio as a randomized clinical trial progresses, is inefficient as compared to a fixed 1:1 randomization ratio in terms of increased required sample size. It is also known that… read more here.
Keywords: adaptive randomization; response adaptive; randomization; time trends ... See more keywords
Kernel-based adaptive randomization toward balance in continuous and discrete covariates
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DOI: 10.5705/ss.202016.0538
Abstract: Covariate balance among different treatment arms is critical in clinical trials, as confounding effects can be effectively eliminated when patients in different arms are alike. To balance the prognostic factors across different arms, we propose… read more here.
Keywords: kernel based; discrete covariates; adaptive randomization; based adaptive ... See more keywords