Statistical inference for response adaptive randomization procedures with adjusted optimal allocation proportions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2016.1269780
Abstract: ABSTRACT Seamless phase II/III clinical trials have attracted increasing attention recently. They mainly use Bayesian response adaptive randomization (RAR) designs. There has been little research into seamless clinical trials using frequentist RAR designs because of… read more here.
Keywords: response adaptive; allocation proportions; statistical inference; adaptive randomization ... See more keywords
An alternative metric for evaluating the potential patient benefit of response-adaptive randomization procedures.
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DOI: 10.1111/biom.13673
Abstract: When planning a two-arm group sequential clinical trial with a binary primary outcome that has severe implications for quality of life (e.g., mortality), investigators may strive to find the design that maximizes in-trial patient benefit.… read more here.
Keywords: adaptive randomization; response adaptive; patient benefit; trial ... See more keywords
Familywise error rate control for block response-adaptive randomization.
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DOI: 10.1177/09622802231167437
Abstract: Response-adaptive randomization allows the probabilities of allocating patients to treatments in a clinical trial to change based on the previously observed response data, in order to achieve different experimental goals. One concern over the use… read more here.
Keywords: adaptive randomization; response adaptive; error rate; response ... See more keywords
Time trends with response-adaptive randomization: The inevitability of inefficiency
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DOI: 10.1177/17407745211065762
Abstract: Response-adaptive randomization, which changes the randomization ratio as a randomized clinical trial progresses, is inefficient as compared to a fixed 1:1 randomization ratio in terms of increased required sample size. It is also known that… read more here.
Keywords: adaptive randomization; response adaptive; randomization; time trends ... See more keywords
Kernel-based adaptive randomization toward balance in continuous and discrete covariates
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DOI: 10.5705/ss.202016.0538
Abstract: Covariate balance among different treatment arms is critical in clinical trials, as confounding effects can be effectively eliminated when patients in different arms are alike. To balance the prognostic factors across different arms, we propose… read more here.
Keywords: kernel based; discrete covariates; adaptive randomization; based adaptive ... See more keywords