Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30989
Abstract: The survival benefit of sorafenib for hepatocellular carcinoma (HCC) patients is unsatisfactory due to the development of adaptive resistance. Increasing evidence has demonstrated that drug resistance can be acquired by cancer cells by activating a… read more here.
Keywords: hepatocellular carcinoma; combination; shp2; sorafenib ... See more keywords
Using Reverse Phase Protein Array (RPPA) to Identify and Target Adaptive Resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9755-5_14
Abstract: Tumor cells and the tumor ecosystem rapidly evolve in response to therapy. This tumor evolution results in the rapid emergence of drug resistance that limits the magnitude and duration of response to therapy including chemotherapy,… read more here.
Keywords: protein; adaptive resistance; resistance; reverse phase ... See more keywords
Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-017-1932-3
Abstract: Irreversible electroporation (IRE) can be used to treat cancer by electrical pulses, with advantages over traditional thermal approaches. Here we assess for the first time the IRE response of pancreatic cancer, one of the deadliest… read more here.
Keywords: irreversible electroporation; ire; pancreatic cancer; adaptive resistance ... See more keywords
Adaptive resistance evolution of V. cholerae to doxycycline associated with spontaneous mutation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106097
Abstract: Cholera caused by the Gram negative bacterium Vibrio cholerae has been a serious threat in under developed countries. Though rehydration therapy has been the mainstay of the disease management, antibiotics are also being used as… read more here.
Keywords: evolution cholerae; adaptive resistance; resistance; resistance evolution ... See more keywords
Overcoming adaptive resistance in AML
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00172-y
Abstract: New classes of HIV inhibitors that can suppress drugresistant viral variants and exhibit longlasting activity are needed. Here, Yant et al. report the identification of GSCA1, a smallmolecule inhibitor of the HIV-1 capsid protein. In… read more here.
Keywords: resistance aml; overcoming adaptive; adaptive resistance; activity ... See more keywords
Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17709-0
Abstract: Swarming is a form of collective bacterial motion enabled by flagella on the surface of semi-solid media. Swarming populations exhibit non-genetic or adaptive resistance to antibiotics, despite sustaining considerable cell death. Here, we show that… read more here.
Keywords: cells release; adaptive resistance; resistance; dead cells ... See more keywords
Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to Elizabethkingia meningoseptica.
Sign Up to like & getrecommendations! Published in 2023 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0179
Abstract: Elizabethkingia meningoseptica is an uncommonly encountered multidrug-resistant gram-negative bacterium that causes infections primarily among vulnerable hosts. A true opportunistic pathogen, its ability to cause severe sepsis and complicated infection in selected patients has been noted.… read more here.
Keywords: elizabethkingia meningoseptica; infection due; infection; adaptive resistance ... See more keywords
Pharmacodynamics of colistin resistance in carbapenemase-producing Klebsiella pneumoniae: the double-edged sword of heteroresistance and adaptive resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001565
Abstract: Introduction. The presence of heteroresistant subpopulations and the development of resistance during drug exposure (adaptive resistance) limits colistin's efficacy against carbapenemase-producing Klebsiella pneumoniae (CP-Kp) isolates.Hypothesis/Gap statement. The pharmacokinetic/pharmacodynamic (PK/PD) characteristics of both types of colistin… read more here.
Keywords: producing klebsiella; adaptive resistance; resistance; carbapenemase producing ... See more keywords
An Adaptive Resistance Perturbation Based MPPT Algorithm for Photovoltaic Applications
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.3034283
Abstract: This paper proposes a Resistance perturbation based maximum power point tracking (MPPT) with an adaptive control limit algorithm to extract the maximum power from solar photovoltaic (PV) array. This algorithm consists of two main functions,… read more here.
Keywords: resistance; algorithm; perturbation based; adaptive resistance ... See more keywords
Transcriptome-Level Signatures in Gene Expression and Gene Expression Variability during Bacterial Adaptive Evolution
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DOI: 10.1128/msphere.00009-17
Abstract: Even initially sensitive bacteria can rapidly thwart antibiotic treatment through stress response processes known as adaptive resistance. Adaptive resistance fosters transient tolerance increases and the emergence of mutations conferring heritable drug resistance. In order to… read more here.
Keywords: adaptation; adaptive resistance; resistance; gene expression ... See more keywords
Abstract CN05-02: Next generation strategies to overcome adaptive resistance to MAPK-directed therapies
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-cn05-02
Abstract: Adaptive resistance remains a major challenge limiting the clinical effectiveness of inhibitors of oncogenic MAPK signaling (RAF and MEK inhibitors), there is thus a pressing need for compounds and combinatorial strategies that would potently and… read more here.
Keywords: overcome adaptive; resistance; ras activation; adaptive resistance ... See more keywords