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Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30989
Abstract: The survival benefit of sorafenib for hepatocellular carcinoma (HCC) patients is unsatisfactory due to the development of adaptive resistance. Increasing evidence has demonstrated that drug resistance can be acquired by cancer cells by activating a…
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Keywords:
hepatocellular carcinoma;
combination;
shp2;
sorafenib ... See more keywords
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Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9755-5_14
Abstract: Tumor cells and the tumor ecosystem rapidly evolve in response to therapy. This tumor evolution results in the rapid emergence of drug resistance that limits the magnitude and duration of response to therapy including chemotherapy,…
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Keywords:
protein;
adaptive resistance;
resistance;
reverse phase ... See more keywords
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Published in 2017 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-017-1932-3
Abstract: Irreversible electroporation (IRE) can be used to treat cancer by electrical pulses, with advantages over traditional thermal approaches. Here we assess for the first time the IRE response of pancreatic cancer, one of the deadliest…
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Keywords:
irreversible electroporation;
ire;
pancreatic cancer;
adaptive resistance ... See more keywords
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Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106097
Abstract: Cholera caused by the Gram negative bacterium Vibrio cholerae has been a serious threat in under developed countries. Though rehydration therapy has been the mainstay of the disease management, antibiotics are also being used as…
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Keywords:
evolution cholerae;
adaptive resistance;
resistance;
resistance evolution ... See more keywords
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Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00172-y
Abstract: New classes of HIV inhibitors that can suppress drugresistant viral variants and exhibit longlasting activity are needed. Here, Yant et al. report the identification of GSCA1, a smallmolecule inhibitor of the HIV-1 capsid protein. In…
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Keywords:
resistance aml;
overcoming adaptive;
adaptive resistance;
activity ... See more keywords
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Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17709-0
Abstract: Swarming is a form of collective bacterial motion enabled by flagella on the surface of semi-solid media. Swarming populations exhibit non-genetic or adaptive resistance to antibiotics, despite sustaining considerable cell death. Here, we show that…
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Keywords:
cells release;
adaptive resistance;
resistance;
dead cells ... See more keywords
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Published in 2023 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0179
Abstract: Elizabethkingia meningoseptica is an uncommonly encountered multidrug-resistant gram-negative bacterium that causes infections primarily among vulnerable hosts. A true opportunistic pathogen, its ability to cause severe sepsis and complicated infection in selected patients has been noted.…
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Keywords:
elizabethkingia meningoseptica;
infection due;
infection;
adaptive resistance ... See more keywords
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Published in 2022 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001565
Abstract: Introduction. The presence of heteroresistant subpopulations and the development of resistance during drug exposure (adaptive resistance) limits colistin's efficacy against carbapenemase-producing Klebsiella pneumoniae (CP-Kp) isolates.Hypothesis/Gap statement. The pharmacokinetic/pharmacodynamic (PK/PD) characteristics of both types of colistin…
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Keywords:
producing klebsiella;
adaptive resistance;
resistance;
carbapenemase producing ... See more keywords
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Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.3034283
Abstract: This paper proposes a Resistance perturbation based maximum power point tracking (MPPT) with an adaptive control limit algorithm to extract the maximum power from solar photovoltaic (PV) array. This algorithm consists of two main functions,…
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Keywords:
resistance;
algorithm;
perturbation based;
adaptive resistance ... See more keywords
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Published in 2017 at "mSphere"
DOI: 10.1128/msphere.00009-17
Abstract: Even initially sensitive bacteria can rapidly thwart antibiotic treatment through stress response processes known as adaptive resistance. Adaptive resistance fosters transient tolerance increases and the emergence of mutations conferring heritable drug resistance. In order to…
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Keywords:
adaptation;
adaptive resistance;
resistance;
gene expression ... See more keywords
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Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-cn05-02
Abstract: Adaptive resistance remains a major challenge limiting the clinical effectiveness of inhibitors of oncogenic MAPK signaling (RAF and MEK inhibitors), there is thus a pressing need for compounds and combinatorial strategies that would potently and…
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Keywords:
overcome adaptive;
resistance;
ras activation;
adaptive resistance ... See more keywords