An Adaptive Treatment to Improve Positive Airway Pressure (PAP) Adherence in Patients With Obstructive Sleep Apnea: A Proof of Concept Trial
Sign Up to like & getrecommendations! Published in 2017 at "Behavioral Sleep Medicine"
DOI: 10.1080/15402002.2015.1135292
Abstract: Despite the benefits of positive airway pressure (PAP) treatment, rates of adherence to treatment are suboptimal. This proof-of-concept study assessed the feasibility, acceptability, and clinical significance of an adaptive treatment strategy to improve adherence to… read more here.
Keywords: airway pressure; adaptive treatment; treatment; positive airway ... See more keywords
Adaptive treatment strategies for chronic conditions: shared-parameter G-estimation with an application to rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Biostatistics"
DOI: 10.1093/biostatistics/kxaa033
Abstract: Most estimation algorithms for adaptive treatment strategies assume that treatment rules at each decision point are independent from one another in the sense that they do not possess any common parameters. This is often unrealistic,… read more here.
Keywords: estimation; adaptive treatment; parameter estimation; shared parameter ... See more keywords
Planning adaptive treatment by longitudinal response assessment implementing MR imaging, liquid biopsy and analysis of microenvironment during neoadjuvant treatment of rectal cancer (PRIMO)
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033575
Abstract: Introduction: Conducting neoadjuvant chemoradiotherapy (CRT) and additional preoperative consolidating chemotherapy (CTx), that is, total neoadjuvant therapy (TNT), improves local control and complete response (CR) rates in locally advanced rectal cancer (LARC), putting the focus on… read more here.
Keywords: adaptive treatment; response assessment; rectal cancer; treatment ... See more keywords
Adaptive treatment allocation for comparative clinical studies with recurrent events data.
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DOI: 10.1111/biom.13117
Abstract: In long-term clinical studies, recurrent event data are sometimes collected and used to contrast the efficacies of two different treatments. The event re-occurrence rates can be compared using the popular negative binomial model, which incorporates… read more here.
Keywords: clinical studies; adaptive treatment; treatment; studies recurrent ... See more keywords
Abstract 5694: Adaptive treatment scheduling of PARP inhibitors in ovarian cancer: Using mathematical modeling to assess clinical feasibility and estimate potential benefits
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5694
Abstract: PARP inhibitors (PARPis) are revolutionizing the treatment of ovarian cancer. Yet for many patients these improvements come at the cost of physical and financial toxicity and responses are typically temporary due to emerging drug resistance.… read more here.
Keywords: ovarian cancer; adaptive treatment; parp inhibitors; model ... See more keywords
Response-adaptive treatment randomization for multiple comparisons of treatments with recurrent event responses
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DOI: 10.1177/09622802221095244
Abstract: Recurrent event responses are frequently encountered during clinical trials of treatments for certain diseases, such as asthma. The recurrence rates of different treatments are often compared by applying the negative binomial model. In addition, a… read more here.
Keywords: treatment; response adaptive; adaptive treatment; treatment allocation ... See more keywords