Over-accrual in Bayesian adaptive trials with continuous futility stopping.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical trials"
DOI: 10.1177/17407745231154685
Abstract: Background: We explore frequentist operating characteristics of a Bayesian adaptive design that allows continuous early stopping for futility. In particular, we focus on the power versus sample size relationship when more patients are accrued than… read more here.
Keywords: stopping futility; bayesian adaptive; futility; adaptive trials ... See more keywords
Bayesian adaptive trials for rare cardiovascular conditions.
Sign Up to like & getrecommendations! Published in 2018 at "Future cardiology"
DOI: 10.2217/fca-2017-0040
Abstract: Escalating costs of cardiovascular trials are limiting medical innovations, prompting the development of more efficient and flexible study designs. The Bayesian paradigm offers a framework conducive to adaptive trial methodologies and is well suited for… read more here.
Keywords: cardiovascular conditions; study; bayesian adaptive; trials rare ... See more keywords