Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0785-y
Abstract: Adaptor proteins containing the pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif (APPLs) are multifunctional adaptor proteins involved in regulating many biological activities and processes. The newly identified metabolic factor APPL2 showed the… read more here.
Keywords: appl2; neurogenesis; hippocampal neurogenesis; glucocorticoid receptor ... See more keywords
Bioactive modulators targeting STING adaptor in cGAS-STING pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.11.007
Abstract: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-pathway triggers innate immune responses by recognizing cytosolic DNA. Recent studies revealed that STING adaptor associates with various diseases, and several modulators targeting STING have been identified… read more here.
Keywords: cgas; sting pathway; targeting sting; sting adaptor ... See more keywords
Signal-transducing adaptor protein-1 and -2 in hematopoiesis and diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental hematology"
DOI: 10.1016/j.exphem.2021.11.002
Abstract: Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment. Upon activation,… read more here.
Keywords: protein; hematopoiesis; adaptor protein; transducing adaptor ... See more keywords
Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01273
Abstract: The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and modulators of its interactions with different regulatory proteins are in high demand because they modulate PRMT5 substrate selectivity. We describe a strategy for… read more here.
Keywords: prmt5 adaptor; interaction; adaptor protein; adaptor ... See more keywords
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14133
Abstract: Danger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain (TIR)-containing adaptors and proinflammatory transcription factors such as NF-κB, occurs in many cell types; however, additional mechanisms are… read more here.
Keywords: production; non tir; tlr; proinflammatory cytokine ... See more keywords
Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01697-9
Abstract: Peptidoglycan (PG) is a highly cross-linked, protective mesh-like sacculus that surrounds the bacterial cytoplasmic membrane. Expansion of PG is tightly coupled to growth of a bacterial cell and requires hydrolases to cleave the cross-links for… read more here.
Keywords: degradation; protease prc; pdz; pdz protease ... See more keywords
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208941120
Abstract: Significance Chaperones are key players in cellular homeostasis that can prevent potentially toxic protein misfolding and aggregation and allow stalled processes to resolve and continue. One of them is a AAA+ ATPase, p97, that acts… read more here.
Keywords: atpase p97; p97; adaptor; aaa atpase ... See more keywords
Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Thyroid"
DOI: 10.1089/thy.2022.0163
Abstract: Background: The sodium/iodide symporter (NIS) is a transmembrane protein located on the basolateral membrane of thyrocytes. Despite its physiological and clinical relevance, little is known about the mechanisms that mediate NIS subcellular sorting. In the… read more here.
Keywords: clathrin adaptor; adaptor complexes; nis; adaptor ... See more keywords
Ventilating the Bearded: A Randomized Crossover Trial Comparing a Novel Bag-Valve-Guedel Adaptor to a Standard Mask.
Sign Up to like & getrecommendations! Published in 2020 at "Military medicine"
DOI: 10.1093/milmed/usz378
Abstract: INTRODUCTION Emergency field ventilation using bag-valve face mask devices can be difficult to perform, especially in bearded individuals. In view of the increasing numbers of servicemen and civilians sporting a beard or moustache, the issue… read more here.
Keywords: face mask; mask; guedel; adaptor ... See more keywords
Design and Fabrication of a Broadband Millimeter Wave Rectangular-Metallic to Dielectric Rod-Waveguide Adaptor
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on Terahertz Science and Technology"
DOI: 10.1109/tthz.2016.2621738
Abstract: We have designed and fabricated a plastic power adaptor operating in the millimeter range by commercially available injection-molding methods. Both numerical simulations and experimental results demonstrate that broadband and low-loss energy transfer between metallic and… read more here.
Keywords: millimeter; design fabrication; millimeter wave; metallic dielectric ... See more keywords
Cargo-mediated recruitment of the endocytic adaptor protein Sla1 in S. cerevisiae
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.247684
Abstract: ABSTRACT Endocytosis of plasma membrane proteins is mediated by their interaction with adaptor proteins. Conversely, emerging evidence suggests that adaptor protein recruitment to the plasma membrane may depend on binding to endocytic cargo. To test… read more here.
Keywords: adaptor; adaptor protein; recruitment; membrane ... See more keywords