Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
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DOI: 10.1021/acs.jmedchem.9b00136
Abstract: There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulator of… read more here.
Keywords: associated kinase; adaptor associated; structure activity; synthesis structure ... See more keywords
A patent review of adaptor associated kinase 1 (AAK1) inhibitors (2013-present)
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DOI: 10.1080/13543776.2021.1928637
Abstract: ABSTRACT Introduction Adaptor-associated kinase 1 (AAK1) has been proposed as being a promising drug target for the treatment of a variety of neurological and psychiatric disorders, such as schizophrenia, cognitive deficits in schizophrenia, Parkinson’s disease,… read more here.
Keywords: aak1 inhibitors; aak1; associated kinase; adaptor associated ... See more keywords