The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09774-w
Abstract: Vegfc/Vegfr3 signaling is critical for lymphangiogenesis, the sprouting of lymphatic vessels. In zebrafish, cells sprouting from the posterior cardinal vein can either form lymphatic precursor cells or contribute to intersegmental vein formation. Both, the Vegfc-dependent… read more here.
Keywords: sprout; vein; adaptor protein; venous sprout ... See more keywords
Quantification of Inflammasome Adaptor Protein ASC in Biological Samples by Multiple-Reaction Monitoring Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0787-6
Abstract: Inflammation is an integral component of many diseases, including chronic kidney disease (CKD). ASC (apoptosis-associated speck-like protein containing CARD, also PYCARD) is the key inflammasome adaptor protein in the innate immune response. Since ASC specks,… read more here.
Keywords: protein; adaptor protein; inflammasome adaptor; multiple reaction ... See more keywords
A highly versatile adaptor protein for the tethering of growth factors to gelatin-based biomaterials.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.01.014
Abstract: In the field of tissue engineering, the tethering of growth factors to tissue scaffolds in an oriented manner can enhance their activity and increase their half-life. We chose to investigate the capture of the basic… read more here.
Keywords: coil; growth; growth factors; adaptor protein ... See more keywords
PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.085
Abstract: The regulated secretory pathway is a specialized form of protein secretion found in endocrine and neuroendocrine cell types. Pro-opiomelanocortin (POMC) is a pro-hormone that utilizes this pathway to be trafficked to dense core secretory granules… read more here.
Keywords: protein; adaptor protein; secretory pathway; pacs ... See more keywords
Signaling adaptor protein Crk is involved in malignant feature of pancreatic cancer associated with phosphorylation of c-Met.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.105
Abstract: Signaling adaptor protein Crk has been shown to play an important role in various human cancers. Crk links tyrosine kinases and guanine nucleotide exchange factors (GEFs) such as C3G and Dock180 to activate small G-proteins… read more here.
Keywords: adaptor protein; signaling adaptor; protein crk; pancreatic cancer ... See more keywords
SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.101
Abstract: SH2 domain-containing inositol 5'-phosphatase (SHIP) has critical functions in regulating signal transduction. In additional to its lipid phosphatase activity, SHIP engages in multiple protein-protein interactions, which can serve to localize either SHIP or its binding… read more here.
Keywords: ship interacts; adaptor protein; interacts adaptor; ship ... See more keywords
Signal-transducing adaptor protein-1 and -2 in hematopoiesis and diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental hematology"
DOI: 10.1016/j.exphem.2021.11.002
Abstract: Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment. Upon activation,… read more here.
Keywords: protein; hematopoiesis; adaptor protein; transducing adaptor ... See more keywords
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01966
Abstract: Adaptor protein 2-associated kinase 1 (AAK1) is a serine/threonine kinase that was identified as a therapeutic target for the potential treatment of neuropathic pain. Inhibition of AAK1 in the central nervous system, particularly within the… read more here.
Keywords: adaptor protein; protein associated; kinase; associated kinase ... See more keywords
Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01273
Abstract: The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and modulators of its interactions with different regulatory proteins are in high demand because they modulate PRMT5 substrate selectivity. We describe a strategy for… read more here.
Keywords: prmt5 adaptor; interaction; adaptor protein; adaptor ... See more keywords
Autoimmune diseases: Inhibitor of adaptor protein shows self-antigen selectivity
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Immunology"
DOI: 10.1038/nri.2017.5
Abstract: A T cell receptor signalling inhibitor shows efficacy in autoimmune diseases without affecting immune responses to pathogens. read more here.
Keywords: diseases inhibitor; adaptor protein; autoimmune diseases; inhibitor adaptor ... See more keywords
Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20577-3
Abstract: Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. Here, we identify… read more here.
Keywords: sepsis; adaptor protein; targeting adaptor; slp76 rage ... See more keywords