RNA editing by the host ADAR system affects the molecular evolution of the Zika virus
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.3033
Abstract: Abstract Zika virus (ZIKV) is a mosquito‐transmitted flavivirus, linked to microcephaly and fetal death in humans. Here, we investigate whether host‐mediated RNA editing of adenosines (ADAR) plays a role in the molecular evolution of ZIKV.… read more here.
Keywords: evolution; molecular evolution; rna editing; zika virus ... See more keywords
An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60155-z
Abstract: Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins. ADAR’s adenosine-to-inosine (effectively A-to-G) deamination activity can be… read more here.
Keywords: rna base; small nuclear; base editing; rna ... See more keywords
Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112663119
Abstract: Significance Viral RNA may be edited by enzymes of the ADAR family that deaminate adenosine residues with ensuing A→G mutations. We found multiple A→G mutations in minor viral populations of the SARS-CoV-2 genome. A→G mutations… read more here.
Keywords: viral populations; adar; viral rna; minor viral ... See more keywords
ADAR editing in viruses: an evolutionary force to reckon with.
Sign Up to like & getrecommendations! Published in 2021 at "Genome biology and evolution"
DOI: 10.1093/gbe/evab240
Abstract: Adenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that play a dynamic and nuanced role in regulating transcriptome and proteome diversity. This editing can be highly selective, affecting a specific site within… read more here.
Keywords: editing viruses; adar editing; viruses evolutionary; role ... See more keywords
An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa025
Abstract: Abstract The RNA-editing protein ADAR is essential for early development in the mouse. Genetic evidence suggests that A to I editing marks endogenous RNAs as ‘self’. Today, different Adar knockout alleles have been generated that… read more here.
Keywords: phenotype; rescued mavs; deletion adar; internal deletion ... See more keywords
EXTH-78. Pharmacologically targeting an RNA editor for H3K27M+ gliomas
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1411
Abstract: Diffuse midline glioma (DMG) is the most aggressive and lethal pediatric brain tumor, with no effective therapies to date. Immune checkpoint blockade (ICB) has failed clinically in DMG, largely due to limited T cell infiltration,… read more here.
Keywords: h3k27m; dmg; rna seq; rna ... See more keywords
The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aah3941
Abstract: Editing of FAK mRNA by the enzyme ADAR in lung adenocarcinoma cells promotes migration and invasion. Metastatic edits to FAK Drugs that inhibit cell migration pathways, such as that mediated by the kinase FAK, may… read more here.
Keywords: lung adenocarcinoma; fak; enzyme adar; migration invasion ... See more keywords
The Interplay between RNA Editing Regulator ADAR1 and Immune Environment in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Oncology"
DOI: 10.1155/2023/9315027
Abstract: An abnormality in the regulation of adenosine deaminase acting on RNA (ADAR) enzymes, which catalyzed adenosine-to-inosine (A-to-I) RNA editing, was closely associated with the highly aggressive biologic behavior and poor prognosis in many malignancies. In… read more here.
Keywords: rna editing; adar; immune environment; adar mrna ... See more keywords
Tripartite motif 47 promotes the development of thyroid carcinoma through ADAR ubiquitination
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine"
DOI: 10.1186/s10020-025-01298-z
Abstract: Tripartite motif 47 (TRIM47) plays a vital role in the carcinogenesis and drug resistance of various cancers, whereas the function of TRIM47 in thyroid carcinoma (TC) remains unclear. Human study and animal experiments were performed.… read more here.
Keywords: tripartite motif; trim47; adar; thyroid carcinoma ... See more keywords
A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing.
Sign Up to like & getrecommendations! Published in 2020 at "RNA"
DOI: 10.1261/rna.072728.119
Abstract: Adenosine-to-inosine RNA editing is an essential posttranscriptional modification catalyzed by adenosine deaminase acting on RNA (ADAR)1 and ADAR2 in mammals. For numerous sites in coding sequences (CDS) and microRNAs, editing is highly conserved and has… read more here.
Keywords: adar1 adar2; rna; adar2; site ... See more keywords
A-to-I RNA Editing Affects lncRNAs Expression after Heat Shock
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.3390/genes9120627
Abstract: Adenosine to inosine (A-to-I) RNA editing is a highly conserved regulatory process carried out by adenosine-deaminases (ADARs) on double-stranded RNA (dsRNAs). Although a considerable fraction of the transcriptome is edited, the function of most editing… read more here.
Keywords: heat shock; rna editing; expression; heat ... See more keywords